دورية أكاديمية
[Biochemical principles of cervix ripening and dilatation].
| العنوان: | [Biochemical principles of cervix ripening and dilatation]. |
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| عنوان ترانسليتريتد: | Biochemische Grundlagen der Zervixreifung und Muttermundseröffnung. |
| المؤلفون: | Rath W; Frauenklinik, RWTH Aachen., Osmers R, Stuhlsatz HW, Adelmann-Grill BC |
| المصدر: | Zeitschrift fur Geburtshilfe und Perinatologie [Z Geburtshilfe Perinatol] 1994 Oct-Dec; Vol. 198 (5-6), pp. 186-95. |
| نوع المنشور: | English Abstract; Journal Article; Review |
| اللغة: | German |
| بيانات الدورية: | Publisher: Enke Country of Publication: Germany NLM ID: 0326205 Publication Model: Print Cited Medium: Print ISSN: 0300-967X (Print) Linking ISSN: 0300967X NLM ISO Abbreviation: Z Geburtshilfe Perinatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Stuttgart, Enke. |
| مواضيع طبية MeSH: | Cervix Uteri/*physiology , Collagen/*metabolism , Fibronectins/*metabolism , Glycosaminoglycans/*metabolism , Labor Onset/*physiology , Proteins/*metabolism , Uterine Contraction/*physiology, Animals ; Collagenases/physiology ; Endopeptidases/physiology ; Extracellular Matrix/physiology ; Female ; Humans ; Immunohistochemistry ; Pregnancy |
| مستخلص: | The central function of the cervix to maintain pregnancy is biochemically characterized by an increased synthesis of collagen, proteins, glycosaminoglycans (GAG) and fibronectin within the extracellular matrix, thus leading to an increase of cervical volume without significant changes of cervical consistency. During the time of cervical ripening we found a marked reduction of collagen concentration, a 2.5-fold increase in GAG content, a significant fall in dermatan sulfate concentrations from 41% to 15% of total GAG content, a 12-fold increase in hyaluronate concentrations, and a marked reduction in fibronectin, demonstrated by immunhistochemical methods. Thus, the loss of collagen and sulfated GAGs may facilitate distensibility in the ripened cervix, while the significant gain in hyaluronate associated with hydratation may explain the soft and swollen consistency. In this connection increased hyaluronate concentrations and degradation of fibronectin may play a trigger role for subsequent cervical dilatation. The dramatic changes of the cervix during parturition occurring within a few hours require the rapid activation and action of catabolic enzyme systems. Our studies showed a significant increase of sialidase-, collagenase- and elastase activities during cervical dilatation. These proteinases originate from polymorphonuclear leucocytes (pml), which accumulate in cervical capillaries at the onset of labor; this is followed by a massive leucocyte infiltration of the cervical stroma at the beginning of cervical dilatation and a degranulation of the pml at further dilatation, thus releasing collagenase and other proteinases. This process is limited by the immediate post partum insudation of the cervix by plasma containing highly potent proteinase inhibitors. The clinical aim of our basic biochemical studies is to develop new concepts in the causal treatment of cervical pathology during pregnancy. |
| Number of References: | 58 |
| المشرفين على المادة: | 0 (Fibronectins) 0 (Glycosaminoglycans) 0 (Proteins) 9007-34-5 (Collagen) EC 3.4.- (Endopeptidases) EC 3.4.24.- (Collagenases) |
| تواريخ الأحداث: | Date Created: 19941001 Date Completed: 19950515 Latest Revision: 20061115 |
| رمز التحديث: | 20240627 |
| PMID: | 7717006 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0300-967X |
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