دورية أكاديمية
Spontaneous cardiac baroreflex in humans. Comparison with drug-induced responses.
| العنوان: | Spontaneous cardiac baroreflex in humans. Comparison with drug-induced responses. |
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| المؤلفون: | Parlow J; Laboratoire de Physiologie de l'Environnement (CNRA SDI 6100), Faculté de Médecine Grange Blanche, Lyon, France., Viale JP, Annat G, Hughson R, Quintin L |
| المصدر: | Hypertension (Dallas, Tex. : 1979) [Hypertension] 1995 May; Vol. 25 (5), pp. 1058-68. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print Cited Medium: Print ISSN: 0194-911X (Print) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]- |
| مواضيع طبية MeSH: | Pressoreceptors/*physiology , Reflex/*drug effects, Adult ; Blood Pressure/drug effects ; Clonidine/pharmacology ; Humans ; Male ; Middle Aged ; Phenylephrine/pharmacology ; Pressoreceptors/drug effects ; Propranolol/pharmacology ; Regression Analysis |
| مستخلص: | We compared two methods of assessment of baroreflex sensitivity in eight supine healthy volunteers during repeated baseline measurements and various conditions of cardiac autonomic blockade. The spontaneous baroreflex method involved computer scanning of recordings of continuous finger arterial pressure and electrocardiogram to locate sequences of three or more beats in which pressure spontaneously increased or decreased, with parallel changes in pulse intervals. The mean regression slope of all these sequences during each study condition was considered to represent the mean spontaneous baroreflex slope. In the drug-induced method, sigmoidal curves were constructed from data obtained by bolus injections of phenylephrine and nitroprusside; the tangents taken at the resting pressure of each of these curves were compared with the mean spontaneous baroreflex slopes. The two methods yielded slopes that were highly correlated (r = .96, P < .001), with significant but similar intraindividual baseline variability. Atropine virtually eliminated the baroreflex slope; subsequent addition of propranolol did not alter it further. Propranolol or clonidine alone increased average baroreflex slope to the extent that they increased resting pulse interval (r = .69 to .83). The spontaneous baroreflex method provides a reliable, noninvasive assessment of human vagal cardiac baroreflex sensitivity within its physiological operating range. |
| المشرفين على المادة: | 1WS297W6MV (Phenylephrine) 9Y8NXQ24VQ (Propranolol) MN3L5RMN02 (Clonidine) |
| تواريخ الأحداث: | Date Created: 19950501 Date Completed: 19950606 Latest Revision: 20220309 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1161/01.hyp.25.5.1058 |
| PMID: | 7737717 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0194-911X |
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| DOI: | 10.1161/01.hyp.25.5.1058 |