دورية أكاديمية
Trinucleotide repeats that expand in human disease form hairpin structures in vitro.
| العنوان: | Trinucleotide repeats that expand in human disease form hairpin structures in vitro. |
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| المؤلفون: | Gacy AM; Mayo Foundation and Graduate School, Rochester, Minnesota, USA., Goellner G, Juranić N, Macura S, McMurray CT |
| المصدر: | Cell [Cell] 1995 May 19; Vol. 81 (4), pp. 533-40. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Print ISSN: 0092-8674 (Print) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, Ma : Cell Press Original Publication: Cambridge, MIT Press. |
| مواضيع طبية MeSH: | Repetitive Sequences, Nucleic Acid*, Genetic Diseases, Inborn/*genetics, Base Sequence ; Humans ; Molecular Sequence Data ; Sequence Analysis |
| مستخلص: | We show that repeating units from all reported disease genes are capable of forming hairpins of common structure and threshold stability. The threshold stability is roughly -50 kcal per hairpin and is influenced by the flanking sequence of the gene. Hairpin stability has two components, sequence and length; only DNA of select sequences and the correct length can form hairpins of threshold energy. There is a correlation among the ability to form hairpins of threshold stability, the sequence selectivity of expansion, and the length dependence of expansion. Additionally, hairpin formation provides a potential structural basis for the constancy of the CCG region of the Huntington's disease gene in individuals and explains the stabilizing effects of AGG interruptions in FMR1 alleles. |
| تواريخ الأحداث: | Date Created: 19950519 Date Completed: 19950629 Latest Revision: 20190705 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0092-8674(95)90074-8 |
| PMID: | 7758107 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0092-8674 |
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| DOI: | 10.1016/0092-8674(95)90074-8 |