دورية أكاديمية
Alteration of PFK subunit protein, synthesis, and mRNA during neonatal brain development.
| العنوان: | Alteration of PFK subunit protein, synthesis, and mRNA during neonatal brain development. |
|---|---|
| المؤلفون: | Mhaskar Y; Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794-9230, USA., Dunaway GA |
| المصدر: | Brain research. Developmental brain research [Brain Res Dev Brain Res] 1995 Mar 16; Vol. 85 (1), pp. 54-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8908639 Publication Model: Print Cited Medium: Print ISSN: 0165-3806 (Print) Linking ISSN: 01653806 NLM ISO Abbreviation: Brain Res Dev Brain Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, |
| مواضيع طبية MeSH: | Animals, Newborn/*growth & development , Animals, Newborn/*metabolism , Brain/*enzymology , Phosphofructokinase-1/*biosynthesis , Phosphofructokinase-1/*metabolism, Animals ; Base Sequence ; Brain/growth & development ; Energy Metabolism/physiology ; Molecular Sequence Data ; Phosphofructokinase-1/ultrastructure ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar |
| مستخلص: | During neonatal maturation of rat brain, a similar biphasic relationship exists between the previously reported pattern of glucose utilization and levels of each type of 6-phosphofructo-1-kinase (PFK) subunit protein, relative synthesis, and mRNA. The increasing amounts of each subunit isoform generally correlated with elevated protein synthesis which was promoted by greater amounts of each type of subunit mRNA. For each parameter, the early phase, 1 to 10 days after birth, was characterized by small increases, and the subsequent period from ten to thirty days postpartum was characterized by a much greater rate of increase. By 30 days after birth, adult values were observed. The apparent efficiency of translation of each type of PFK subunit mRNA in brain suggests that the M-type subunit mRNA is the most efficient and that the L-type subunit mRNA is the least. The greatest relative increases in subunit protein, mRNA, and synthesis were observed for the C-type subunit. Since enhanced translation apparently makes little, if any, contribution, a possible explanation of these phenomena could be increased transcription of the PFK genes. These neonatal changes could involve age-dependent alteration of methylation of the PFK gene promotor(s) and/or activity of effectors of the transcription of the PFK genes. |
| معلومات مُعتمدة: | AG08014 United States AG NIA NIH HHS; HD 16666 United States HD NICHD NIH HHS |
| المشرفين على المادة: | 0 (RNA, Messenger) EC 2.7.1.11 (Phosphofructokinase-1) |
| تواريخ الأحداث: | Date Created: 19950316 Date Completed: 19950714 Latest Revision: 20190830 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/0165-3806(94)00190-b |
| PMID: | 7781167 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0165-3806 |
|---|---|
| DOI: | 10.1016/0165-3806(94)00190-b |