دورية أكاديمية
Circulating interleukin 1 beta and soluble interleukin 2 receptor: evaluation as markers of disease activity in scleroderma.
| العنوان: | Circulating interleukin 1 beta and soluble interleukin 2 receptor: evaluation as markers of disease activity in scleroderma. |
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| المؤلفون: | Patrick MR; Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia., Kirkham BW, Graham M, Harrision LC |
| المصدر: | The Journal of rheumatology [J Rheumatol] 1995 Apr; Vol. 22 (4), pp. 654-8. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Journal Of Rheumatology Publishing Co Country of Publication: Canada NLM ID: 7501984 Publication Model: Print Cited Medium: Print ISSN: 0315-162X (Print) Linking ISSN: 0315162X NLM ISO Abbreviation: J Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Toronto : Journal Of Rheumatology Publishing Co Original Publication: Toronto. |
| مواضيع طبية MeSH: | Interleukin-1/*blood , Receptors, Interleukin-2/*metabolism , Scleroderma, Systemic/*blood, Adult ; Aged ; Blood Sedimentation ; Cyclosporine/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Scleroderma, Localized/blood ; Scleroderma, Localized/drug therapy ; Scleroderma, Localized/physiopathology ; Scleroderma, Systemic/drug therapy ; Scleroderma, Systemic/physiopathology ; Solubility |
| مستخلص: | Objectives: To investigate whether circulating levels of interleukin 1 beta (IL-1 beta) or soluble interleukin 2 receptor (sIL-2R) reflect clinical disease status and response to therapy in scleroderma. Methods: Plasma IL-1 beta and serum sIL-2R were measured by ELISA in 19 patients with limited cutaneous scleroderma (9 with extraesophageal internal organ involvement), 5 patients with diffuse cutaneous scleroderma and internal organ involvement, and 11 healthy controls, as well as serially over 12 months in 4 patients with scleroderma treated with cyclosporine. Results: IL-1 beta levels were similar in scleroderma and control subject groups. sIL-2R levels were significantly higher in subjects with scleroderma involving internal organs (elevated in 93%), and correlated with erythrocyte sedimentation rate. sIL-2R levels decreased over 12 months in 2 of 4 patients taking cyclosporine in whom other variables remained unchanged. Conclusions: Elevated serum sIL-2R is a marker of internal organ involvement in scleroderma and warrants further investigation in assessing disease prognosis and response to therapy. |
| المشرفين على المادة: | 0 (Interleukin-1) 0 (Receptors, Interleukin-2) 83HN0GTJ6D (Cyclosporine) |
| تواريخ الأحداث: | Date Created: 19950401 Date Completed: 19950727 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 7791158 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0315-162X |
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