دورية أكاديمية
Short-course ciprofloxacin treatment of acute uncomplicated urinary tract infection in women. The minimum effective dose. The Urinary Tract Infection Study Group [corrected].
| العنوان: | Short-course ciprofloxacin treatment of acute uncomplicated urinary tract infection in women. The minimum effective dose. The Urinary Tract Infection Study Group [corrected]. |
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| المؤلفون: | Iravani A; Central Florida Medical Research Center, Orlando., Tice AD, McCarty J, Sikes DH, Nolen T, Gallis HA, Whalen EP, Tosiello RL, Heyd A, Kowalsky SF, et. al. |
| المصدر: | Archives of internal medicine [Arch Intern Med] 1995 Mar 13; Vol. 155 (5), pp. 485-94. |
| نوع المنشور: | Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Assn Country of Publication: United States NLM ID: 0372440 Publication Model: Print Cited Medium: Print ISSN: 0003-9926 (Print) Linking ISSN: 00039926 NLM ISO Abbreviation: Arch Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, American Medical Assn. |
| مواضيع طبية MeSH: | Ciprofloxacin/*therapeutic use , Urinary Tract Infections/*drug therapy, Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Ciprofloxacin/administration & dosage ; Ciprofloxacin/adverse effects ; Colony Count, Microbial ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Middle Aged ; Prospective Studies ; Recurrence ; Risk Factors ; Treatment Outcome ; Urinary Tract Infections/microbiology |
| مستخلص: | Background: Three studies were undertaken to determine the minimum effective dosing regimen of ciprofloxacin for the treatment of acute, symptomatic, uncomplicated lower urinary tract infection. Methods: All studies were multicenter, prospective, randomized, double-blind trials. A total of 970 evaluable patients with a diagnosis of urinary tract infection received oral ciprofloxacin (200 mg to 500 mg daily in one or two divided doses for 1, 3, 5, or 7 days) or norfloxacin (400 mg twice daily [BID] for 7 days). The primary measure of efficacy was bacteriologic eradication at the end of therapy. Results: In study 1, bacteriologic eradication was reported in 95 (89%) and 101 (98%) of patients in the groups who received ciprofloxacin, 500-mg single dose and 250 mg BID for 7 days, respectively. Clinical success occurred in 101 patients (94%) who received a 500-mg single dose and in 103 patients (100%) who were administered 250 mg BID for 7 days. In study 2, eradication rates in the groups who received ciprofloxacin, 100 mg BID for 3 days, 250 mg BID for 3 days, and 250 mg BID for 7 days, were 98 (93%), 95 (90%), and 98 (93%), respectively. Clinical success was reported in 102 (97%), 105 (100%), and 104 (98%) of the patients, respectively. In study 3, the eradication rates in the groups who received ciprofloxacin in dosages of 500 mg once daily for 3 days and 500 mg once daily for 5 days and norfloxacin in a dosage of 400 mg BID for 7 days were 137 (92%), 134 (90%), and 133 (94%) of the women, respectively. Clinical success was the same (97%) in all three groups. Overall, short-course (either 3- or 5-day) therapy with ciprofloxacin was statistically equivalent to conventional (7-day) therapy with either ciprofloxacin or norfloxacin. Single-dose ciprofloxacin therapy was statistically less effective than conventional treatment. Conclusions: Ciprofloxacin at a dosage of 100 mg BID for 3 days was the minimum effective dose for the treatment of uncomplicated urinary tract infection in women. |
| التعليقات: | Erratum in: Arch Intern Med 1995 Apr 24;155(8):871. Comment in: Arch Intern Med. 1996 Jan 8;156(1):111-3. (PMID: 8526690) |
| المشرفين على المادة: | 5E8K9I0O4U (Ciprofloxacin) |
| تواريخ الأحداث: | Date Created: 19950313 Date Completed: 19950323 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 7864704 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0003-9926 |
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