دورية أكاديمية
Antibodies to high mobility group proteins in systemic sclerosis.
| العنوان: | Antibodies to high mobility group proteins in systemic sclerosis. |
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| المؤلفون: | Ayer LM; Department of Medicine, University of Calgary, AB, Canada., Sénecal JL, Martin L, Dixon GH, Fritzler MJ |
| المصدر: | The Journal of rheumatology [J Rheumatol] 1994 Nov; Vol. 21 (11), pp. 2071-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Journal Of Rheumatology Publishing Co Country of Publication: Canada NLM ID: 7501984 Publication Model: Print Cited Medium: Print ISSN: 0315-162X (Print) Linking ISSN: 0315162X NLM ISO Abbreviation: J Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Toronto : Journal Of Rheumatology Publishing Co Original Publication: Toronto. |
| مواضيع طبية MeSH: | Autoantibodies/*blood , High Mobility Group Proteins/*immunology , Raynaud Disease/*immunology , Scleroderma, Systemic/*immunology, Autoantibodies/immunology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoblotting |
| مستخلص: | Objective: To determine the prevalence of autoantibodies to high mobility group (HMG) proteins in systemic sclerosis (SSc). Methods: One hundred ninety-seven unselected sera from patients diagnosed as SSc (n = 180) or Raynaud's phenomenon (RP) (n = 17) were tested for HMG autoantibodies by ELISA and immunoblotting. Results: Seventy-one of the 180 (39.0%) SSc sera bound to HMG proteins in an ELISA: 56 (31%) to HMG-1 and/or HMG-2; 29 (16%) to HMG-14/17. In the same assay, 7 of 17 RP sera (41%) bound to HMG proteins: 4 (23%) to HMG-1 and/or HMG-2, and 5 (29%) to HMG-14/17. The specificity of HMG binding was confirmed by immunoblotting. Conclusion: Antibodies to HMG proteins, particularly to HMG-1 and HMG-2 are found in about 1/3 of SSc Sera. Since HMG-1 and HMG-2 have a role in transcription, these observations further implicate transcriptional complexes as targets of autoantibodies in scleroderma. This is the first published report of HMG autoantibodies in scleroderma. |
| المشرفين على المادة: | 0 (Autoantibodies) 0 (High Mobility Group Proteins) |
| تواريخ الأحداث: | Date Created: 19941101 Date Completed: 19950330 Latest Revision: 20100324 |
| رمز التحديث: | 20221213 |
| PMID: | 7869312 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0315-162X |
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