دورية أكاديمية
Ovarian tumors in a cohort of infertile women.
| العنوان: | Ovarian tumors in a cohort of infertile women. |
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| المؤلفون: | Rossing MA; Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle., Daling JR, Weiss NS, Moore DE, Self SG |
| المصدر: | The New England journal of medicine [N Engl J Med] 1994 Sep 22; Vol. 331 (12), pp. 771-6. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Print ISSN: 0028-4793 (Print) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Boston, Massachusetts Medical Society. |
| مواضيع طبية MeSH: | Clomiphene/*adverse effects , Infertility, Female/*drug therapy , Ovarian Neoplasms/*chemically induced, Adult ; Case-Control Studies ; Clomiphene/therapeutic use ; Cohort Studies ; Confidence Intervals ; Female ; Follow-Up Studies ; Humans ; Infertility, Female/epidemiology ; Middle Aged ; Ovarian Neoplasms/epidemiology ; Regression Analysis ; Risk ; Washington/epidemiology |
| مستخلص: | Background: Case reports and the results of a recent case-control study have raised questions about the potential neoplastic effects of medications used as treatment for infertility. Methods: We examined the risk of ovarian tumors in a cohort of 3837 women evaluated for infertility between 1974 and 1985 in Seattle. Computer linkage with a population-based tumor registry was used to identify women in whom tumors were diagnosed before January 1, 1992. Data on infertility testing and treatment were abstracted from the medical records of women who had ovarian cancer and those of a randomly selected comparison group. The risk of ovarian tumors associated with exposure to ovulation-inducing medications was assessed through an age-standardized comparison with the rate of ovarian tumors in the general population, and Cox regression analysis was used to compare the risk of cancer among women who received these medications with the risk among infertile women who did not receive them. Results: There were 11 invasive or borderline malignant ovarian tumors, as compared with an expected number of 4.4 (standardized incidence ratio, 2.5; 95 percent confidence interval, 1.3 to 4.5). Nine of the women in whom ovarian tumors developed had taken clomiphene; the adjusted relative risk among these women, as compared with that among infertile women who had not taken this drug, was 2.3 (95 percent confidence interval, 0.5 to 11.4). Five of the nine women had taken the drug during 12 or more monthly cycles. This period of treatment was associated with an increased risk of ovarian tumors among both women with ovarian abnormalities and those without apparent abnormalities (relative risk, 11.1; 95 percent confidence interval, 1.5 to 82.3), whereas treatment with the drug for less than one year was not associated with an increased risk. Conclusions: Prolonged use of clomiphene may increase the risk of a borderline or invasive ovarian tumor. |
| التعليقات: | Comment in: N Engl J Med. 1995 May 11;332(19):1301; author reply 1302. (PMID: 7708078) Comment in: N Engl J Med. 1994 Sep 22;331(12):805-6. (PMID: 7772101) Comment in: N Engl J Med. 1995 May 11;332(19):1300; author reply 1302. (PMID: 7772146) |
| معلومات مُعتمدة: | N01-CN-05230 United States CN NCI NIH HHS; R35 CA-39779 United States CA NCI NIH HHS |
| المشرفين على المادة: | 1HRS458QU2 (Clomiphene) |
| تواريخ الأحداث: | Date Created: 19940922 Date Completed: 19940922 Latest Revision: 20220410 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1056/NEJM199409223311204 |
| PMID: | 8065405 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0028-4793 |
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| DOI: | 10.1056/NEJM199409223311204 |