دورية أكاديمية
The dependence potential of short half-life benzodiazepines: a meta-analysis.
| العنوان: | The dependence potential of short half-life benzodiazepines: a meta-analysis. |
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| المؤلفون: | Hallfors DD; Health Policy Institute, Brandeis University, Waltham, MA 02254-9110., Saxe L |
| المصدر: | American journal of public health [Am J Public Health] 1993 Sep; Vol. 83 (9), pp. 1300-4. |
| نوع المنشور: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Public Health Association Country of Publication: United States NLM ID: 1254074 Publication Model: Print Cited Medium: Print ISSN: 0090-0036 (Print) Linking ISSN: 00900036 NLM ISO Abbreviation: Am J Public Health Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : American Public Health Association Original Publication: New York [etc.] |
| مواضيع طبية MeSH: | Anti-Anxiety Agents/*pharmacokinetics , Substance-Related Disorders/*physiopathology, Benzodiazepines ; Half-Life ; Humans |
| مستخلص: | Objectives: The dependence potential of benzodiazepine medications is now widely recognized, but uncertainty exists as to whether use of short half-life vs long half-life drugs results in greater dependence. The present study reports a meta-analysis of the extant research to evaluate the dependence potential of different types of benzodiazepines. Method: Seven studies were found that specifically compared long half-life and short half-life benzodiazepines and allowed statistical comparison by their homogeneous dependent variables. Drugs in these studies were used as daytime sedatives. Results: Substantial evidence was found for differential effects of short vs long half-life drugs at withdrawal. In all studies, dropouts were higher among short half-life subjects. In the random-assignment short-term use studies, Hamilton Anxiety Scale scores showed higher incidence of rebound among subjects who used the short half-life drugs. Conclusions: The present meta-analysis confirms clinical impressions of the greater dependence potential of short vs long half-life benzodiazepines. Doctors, patients, and policymakers need to be informed so as to avoid harm to the public health through unintended drug dependence. |
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| المشرفين على المادة: | 0 (Anti-Anxiety Agents) 12794-10-4 (Benzodiazepines) |
| تواريخ الأحداث: | Date Created: 19930901 Date Completed: 19930927 Latest Revision: 20190514 |
| رمز التحديث: | 20240627 |
| مُعرف محوري في PubMed: | PMC1694983 |
| DOI: | 10.2105/ajph.83.9.1300 |
| PMID: | 8103297 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0090-0036 |
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| DOI: | 10.2105/ajph.83.9.1300 |