دورية أكاديمية
Potentiation of canine pancreatic bicarbonate output by oleic acid is not neurally dependent.
| العنوان: | Potentiation of canine pancreatic bicarbonate output by oleic acid is not neurally dependent. |
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| المؤلفون: | Fink AS; Department of Surgery, University of Cincinnati Medical Center, Ohio., Brodish RJ, Kuvshinoff BW, Irving M, DeMar AR |
| المصدر: | Pancreas [Pancreas] 1994 Mar; Vol. 9 (2), pp. 230-9. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8608542 Publication Model: Print Cited Medium: Print ISSN: 0885-3177 (Print) Linking ISSN: 08853177 NLM ISO Abbreviation: Pancreas Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [New York, N.Y.] : Raven Press, [c1986- |
| مواضيع طبية MeSH: | Bicarbonates/*metabolism , Oleic Acids/*pharmacology , Pancreas/*drug effects , Pancreas/*innervation, Animals ; Denervation ; Dogs ; Neural Pathways/drug effects ; Oleic Acid ; Pancreas/metabolism ; Pancreatic Fistula ; Perfusion ; Phenylalanine/pharmacology ; Serum Albumin, Bovine |
| مستخلص: | To study neural involvement in potentiation of acid-induced pancreatic bicarbonate output, six dogs underwent extrapancreatic denervation and pancreatic fistula creation. Pancreatic responses to secretin (16 and 32 ng/kg/h) and cholecystokinin (50 ng/kg/h) were then assessed. The duodenum was then perfused with three sets of perfusates. The first set contained hydrochloric acid with either D- or L-phenylalanine. The second set contained bovine serum albumin and hydrochloric acid with or without oleic acid; the albumin and acid were varied so that each 50 ml contained 1, 2, or 4 meq titratable acid (pH 2.0-4.5). The third set was identical to the second except for initial pH of 3.5. Pancreatic responses predicted upon addition of cholecystokinin to secretin, L-phenylalanine to hydrochloric acid, or oleic acid to bovine serum albumin were compared with observed responses. At both doses, secretin-induced bicarbonate output was increased by cholecystokinin (16 ng/kg/h: 0.88 +/- 0.29 meq/15 min; 32 ng/kg/h: 1.01 +/- 0.23 meq/15 min). The latter significantly exceeded predicted output (16 ng/kg/h: 0.38 +/- 0.10 meq/15 min; 32 ng/kg/h: 0.58 +/- 0.15 meq/15 min), verifying potentiation. L-phenylalanine failed to potentiate bicarbonate output evoked by acidified D-phenylalanine. In contrast, addition of oleic acid to pH 2.0 or 3.5 bovine serum albumin potentiated bicarbonate output. These data suggest that enteropancreatic reflexes mediate potentiation of acid-induced pancreatic bicarbonate output by amino acids, but not by fatty acids. |
| المشرفين على المادة: | 0 (Bicarbonates) 0 (Oleic Acids) 27432CM55Q (Serum Albumin, Bovine) 2UMI9U37CP (Oleic Acid) 47E5O17Y3R (Phenylalanine) |
| تواريخ الأحداث: | Date Created: 19940301 Date Completed: 19940621 Latest Revision: 20190904 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/00006676-199403000-00014 |
| PMID: | 8190725 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0885-3177 |
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| DOI: | 10.1097/00006676-199403000-00014 |