دورية أكاديمية
Transepidermal induction of contact hypersensitivity in mice with a water-soluble hapten.
| العنوان: | Transepidermal induction of contact hypersensitivity in mice with a water-soluble hapten. |
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| المؤلفون: | Shimizu T; Department of Microbiology and Immunology, University of Miami School of Medicine, Florida., Munn CG, Streilein JW |
| المصدر: | The Journal of investigative dermatology [J Invest Dermatol] 1993 Nov; Vol. 101 (5), pp. 749-53. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print Cited Medium: Print ISSN: 0022-202X (Print) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Dermatitis, Contact/*etiology , Haptens/*immunology , Trinitrobenzenesulfonic Acid/*immunology, Animals ; Dose-Response Relationship, Immunologic ; Injections, Intradermal ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Solubility ; Tumor Necrosis Factor-alpha/pharmacology ; Ultraviolet Rays ; Urocanic Acid/pharmacology |
| مستخلص: | An experimental analysis has been conducted on the capacity of a highly-reactive, water soluble hapten, trinitrobenzene sulfonic acid, to induce contact hypersensitivity when applied epicutaneously to body wall skin of normal mice. Application of plastic chambers containing the hapten to murine skin for as little as 1 h produced readily detectable sensitization in several genetically disparate inbred strains. Moreover, the efficiency of sensitization was found to be similar to that following epicutaneous application of this hapten's lipid-soluble cogener, trinitrochlorobenzene. Using this approach, it has been determined that UVB radiation, intradermally injected tumor necrosis factor-alpha, and epicutaneously applied cis-urocanic acid can impair contact hypersensitivity induction by transepidermally delivered trinitrobenzene sulfonic acid, and that animals that fail to become sensitized proceed to acquire hapten-specific unresponsiveness. It is concluded that epicutaneous sensitization to chemically reactive, water-soluble molecules is experimentally attainable if precautions are taken to insure that contact between the hapten solution and the cutaneous surface is maintained for at least 1 h. Understanding the cellular and molecular mechanisms of sensitization and tolerance induction by epicutaneously applied water soluble haptens may prove to be important in understanding the pathogenesis of allergic contact dermatitis that develops to chemicals in the industrial setting, in the environment, and in the clinic. |
| معلومات مُعتمدة: | AI 22072 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Haptens) 0 (Tumor Necrosis Factor-alpha) 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid) G8D26XJJ3B (Urocanic Acid) |
| تواريخ الأحداث: | Date Created: 19931101 Date Completed: 19931126 Latest Revision: 20190723 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1111/1523-1747.ep12371687 |
| PMID: | 8228339 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-202X |
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| DOI: | 10.1111/1523-1747.ep12371687 |