دورية أكاديمية
A nuclear matrix protein stabilized by lead exposure: current knowledge and future prospects.
| العنوان: | A nuclear matrix protein stabilized by lead exposure: current knowledge and future prospects. |
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| المؤلفون: | Shelton KR; Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0614., Egle PM, Bigbee JW, Klann E |
| المصدر: | Neurotoxicology [Neurotoxicology] 1993 Summer-Fall; Vol. 14 (2-3), pp. 61-7. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print Cited Medium: Print ISSN: 0161-813X (Print) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2001- : Amsterdam : Elsevier Science Original Publication: Park Forest South, Ill., Pathotox Publishers. |
| مواضيع طبية MeSH: | Lead Poisoning/*metabolism , Nuclear Proteins/*drug effects, Animals ; Antigens, Nuclear ; Brain/growth & development ; Brain/metabolism ; Forecasting ; Humans ; Inclusion Bodies/drug effects ; Nuclear Proteins/metabolism ; Tumor Cells, Cultured |
| مستخلص: | p32/6.3, a low-abundance, highly conserved nuclear protein, is a target for lead. Very few low abundance nuclear proteins have been described and no others have been associated with lead. Its wide distribution and conservation indicate a fundamental nuclear role. Further, it increases many fold in grey matter of brain and spinal cord during the neonatal period; there are no other identified nuclear proteins which serve as markers for this period of nervous system development. There are several links between lead and p32/6.3. It is a major component of lead-induced intranuclear inclusion bodies from the kidney. Its accumulation in kidney is a relatively early event in the process of lead intoxication. Exposure to lead increases p32/6.3 in mouse neuroblastoma 2a cells within one day, blocking its degradation almost completely. These observations suggest that lead either structurally alters p32/6.3 or inhibits a protease for which p32/6.3 is a substrate. In these lead-treated cells nuclear envelope invaginations and small nuclear bodies increase. The possible involvement of lead and p32/6.3 with the formation and movement of nuclear bodies is discussed. |
| معلومات مُعتمدة: | ES 02377 United States ES NIEHS NIH HHS |
| المشرفين على المادة: | 0 (Antigens, Nuclear) 0 (Nuclear Proteins) |
| تواريخ الأحداث: | Date Created: 19930101 Date Completed: 19940105 Latest Revision: 20071114 |
| رمز التحديث: | 20221213 |
| PMID: | 8247412 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0161-813X |
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