دورية أكاديمية
Heterogenous insulin response to an oral glucose load by patients with the indeterminate clinical form of Chagas' disease.
| العنوان: | Heterogenous insulin response to an oral glucose load by patients with the indeterminate clinical form of Chagas' disease. |
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| المؤلفون: | Guariento ME; Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brasil., Saad MJ, Muscelli EO, Gontijo JA |
| المصدر: | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 1993 May; Vol. 26 (5), pp. 491-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: Print Cited Medium: Print ISSN: 0100-879X (Print) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981- |
| مواضيع طبية MeSH: | Blood Glucose/*analysis , Chagas Disease/*blood , Glucose/*administration & dosage , Insulin/*blood, Adult ; Female ; Glucose Tolerance Test ; Humans ; Insulin/metabolism ; Insulin Secretion ; Male |
| مستخلص: | This study was designed to investigate the behavior of serum glucose and insulin in response to an oral glucose load in chagasic patients with the indeterminate clinical form of the disease. Sixteen chagasic patients and 28 healthy control subjects were studied after an overnight fast and during 2 h after ingestion of 100 g glucose. There were no significant differences in serum glucose levels before and 2 h after the glucose load between chagasic and control subjects. However, in 8 chagasic patients, the total area under the insulin curve was significantly lower (2976 +/- 448 microU ml-1 120 min-1) than in the control (10123 +/- 995 microU ml-1 120 min-1) and in the remaining chagasic patients (9220 +/- 826 microU ml-1 120 min-1). These results suggest that the hypoinsulinemia of this subgroup of chagasic patients may be secondary to reduced insulin secretion and/or to increased peripheral insulin sensitivity probably related to autonomic dysfunction. |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Insulin) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 19930501 Date Completed: 19940119 Latest Revision: 20181217 |
| رمز التحديث: | 20240627 |
| PMID: | 8257938 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0100-879X |
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