دورية أكاديمية
Renal response to amino acid infusion in essential hypertension.
| العنوان: | Renal response to amino acid infusion in essential hypertension. |
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| المؤلفون: | Juncos L; Instituto Privado de Especialidades Medicas, Argentina., Cornejo JC, Pamies-Andreu E, Romero JC |
| المصدر: | Hypertension (Dallas, Tex. : 1979) [Hypertension] 1994 Jan; Vol. 23 (1 Suppl), pp. I225-30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print Cited Medium: Print ISSN: 0194-911X (Print) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]- |
| مواضيع طبية MeSH: | Amino Acids/*pharmacology , Blood Pressure/*drug effects , Enalapril/*pharmacology , Hypertension/*physiopathology , Kidney/*drug effects, Adult ; Aged ; Aldosterone/blood ; Amino Acids/administration & dosage ; Angiotensin II/blood ; Diastole/drug effects ; Diet, Sodium-Restricted ; Female ; Glomerular Filtration Rate/drug effects ; Humans ; Hypertension/diet therapy ; Infusions, Intravenous ; Kidney/blood supply ; Kidney/physiopathology ; Male ; Middle Aged ; Regional Blood Flow/drug effects ; Renin/blood ; Sodium/urine ; Systole/drug effects ; Urine |
| مستخلص: | In the present study, we evaluated the renal response to a 4-hour infusion of amino acids in essential hypertensive patients, as well as the effects that dietary sodium restriction and enalapril (a converting enzyme inhibitor) had on this renal response. During normal sodium intake, amino acid infusion significantly increased renal plasma flow from 383 +/- 58 to 478 +/- 51 mL/min and glomerular filtration rate from 82 +/- 8 to 100 +/- 13 mL/min. All these effects were abolished when the patients received a low sodium diet (40 mmol/d) for 3 days before the amino acid infusion. The administration of enalapril to the patients during sodium restriction restored the amino acid-induced increment in renal plasma flow (from 388 +/- 35 to 573 +/- 48 mL/min) and glomerular filtration rate (from 88 +/- 9 to 103 +/- 10 mL/min). Mean arterial pressure remained unaltered under all experimental conditions. The results show that in patients with essential hypertension dietary sodium restriction prevents amino acid-induced increments in glomerular filtration rate and renal plasma flow and that this effect is restored during the simultaneous administration of enalapril. |
| معلومات مُعتمدة: | HL-16496 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Amino Acids) 11128-99-7 (Angiotensin II) 4964P6T9RB (Aldosterone) 69PN84IO1A (Enalapril) 9NEZ333N27 (Sodium) EC 3.4.23.15 (Renin) |
| تواريخ الأحداث: | Date Created: 19940101 Date Completed: 19940216 Latest Revision: 20190722 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1161/01.hyp.23.1_suppl.i225 |
| PMID: | 8282364 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0194-911X |
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| DOI: | 10.1161/01.hyp.23.1_suppl.i225 |