دورية أكاديمية
Progressive visual deterioration leading to blindness after pediatric heart transplantation.
العنوان: | Progressive visual deterioration leading to blindness after pediatric heart transplantation. |
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المؤلفون: | Schowengerdt KO Jr; Division of Pediatric Cardiology, Texas Children's Hospital, Houston 77030., Gajarski RJ, Denfield S |
المصدر: | Texas Heart Institute journal [Tex Heart Inst J] 1993; Vol. 20 (4), pp. 299-303. |
نوع المنشور: | Case Reports; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: published in the Cardiovascular Surgical Research Laboratories, Texas Heart Institute Country of Publication: United States NLM ID: 8214622 Publication Model: Print Cited Medium: Print ISSN: 0730-2347 (Print) Linking ISSN: 07302347 NLM ISO Abbreviation: Tex Heart Inst J Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Houston, TX : published in the Cardiovascular Surgical Research Laboratories, Texas Heart Institute, c1982- |
مواضيع طبية MeSH: | Blindness/*etiology , Heart Transplantation/*adverse effects , Immunosuppressive Agents/*adverse effects , Pseudotumor Cerebri/*etiology, Child ; Female ; Graft Rejection ; Humans ; Pseudotumor Cerebri/complications ; Time Factors |
مستخلص: | We present the case of a 10-year-old girl who developed visual loss progressing to blindness after orthotopic heart transplantation and an immunosuppressive regimen of cyclosporine, azathioprine, and prednisone. Headaches and visual deterioration began 2 months after transplantation, and a diagnosis of pseudotumor cerebri was made. The patient's visual loss continued despite aggressive medical and surgical therapy, which included bilateral optic nerve sheath fenestration. To our knowledge, permanent visual loss as a late sequela following pediatric heart transplantation and immunosuppressive therapy has not been reported previously in the English literature. Although the cause of visual loss after transplantation in our patient is poorly understood, we conclude that permanent visual loss, although rare, should be considered as a possible late neurologic sequela after pediatric heart transplantation. |
References: | N Engl J Med. 1984 Feb 23;310(8):527. (PMID: 6363932) Bone Marrow Transplant. 1990 Aug;6(2):147-9. (PMID: 2207451) Neurol Clin. 1992 Feb;10(1):145-66. (PMID: 1557000) J Heart Lung Transplant. 1993 Mar-Apr;12(2):252-5. (PMID: 8476898) Neurol Clin. 1988 May;6(2):349-65. (PMID: 3047545) N Engl J Med. 1987 Oct 1;317(14):861-6. (PMID: 3306386) J Heart Lung Transplant. 1992 Sep-Oct;11(5):933-42. (PMID: 1420242) J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1434-7. (PMID: 3069960) Tex Heart Inst J. 1986 Mar;13(1):1-3. (PMID: 15226825) J Heart Transplant. 1990 Nov-Dec;9(6):587-93. (PMID: 2277293) Arch Neurol. 1982 Aug;39(8):461-74. (PMID: 7103794) Neurology. 1986 Sep;36(9):1149-54. (PMID: 3528916) N Engl J Med. 1988 Mar 24;318(12):788-9. (PMID: 3347234) Mayo Clin Proc. 1980 Sep;55(9):541-6. (PMID: 7412408) Pediatrics. 1987 Jan;79(1):138-46. (PMID: 3540834) Br Med J (Clin Res Ed). 1984 Nov 17;289(6455):1347-8. (PMID: 6437543) Arch Neurol. 1984 Mar;41(3):329-30. (PMID: 6582812) Rev Infect Dis. 1990 May-Jun;12(3):393-8. (PMID: 2193345) |
المشرفين على المادة: | 0 (Immunosuppressive Agents) |
تواريخ الأحداث: | Date Created: 19930101 Date Completed: 19940310 Latest Revision: 20181113 |
رمز التحديث: | 20240627 |
مُعرف محوري في PubMed: | PMC325116 |
PMID: | 8298330 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0730-2347 |
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