دورية أكاديمية
Long-term enalapril and hydrochlorothiazide in radiation nephritis.
| العنوان: | Long-term enalapril and hydrochlorothiazide in radiation nephritis. |
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| المؤلفون: | Juncos LI; Private Institute of Medical Specialties, National University of Córdoba, Argentina., Carrasco Dueñas S, Cornejo JC, Broglia CA, Cejas H |
| المصدر: | Nephron [Nephron] 1993; Vol. 64 (2), pp. 249-55. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0331777 Publication Model: Print Cited Medium: Print ISSN: 1660-8151 (Print) Linking ISSN: 16608151 NLM ISO Abbreviation: Nephron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger |
| مواضيع طبية MeSH: | Enalapril/*pharmacology , Hydrochlorothiazide/*pharmacology , Nephritis/*drug therapy , Radiation Injuries, Experimental/*drug therapy, Animals ; Blood Pressure/drug effects ; Hypertension, Renal/prevention & control ; Nephrectomy ; Nephritis/pathology ; Nephritis/physiopathology ; Radiation Injuries, Experimental/pathology ; Radiation Injuries, Experimental/physiopathology ; Rats ; Time Factors |
| مستخلص: | Radiation of the kidney often leads to renal failure. The contribution of arterial hypertension to the development of this complication is unclear. The aim of this study was to determine the renal effects of antihypertensive therapy in 1- and 2-kidney rat models of radiation nephritis. Five groups of Long Evans rats had X-irradiation of the left kidney. In groups 1 and 2, the right kidney was left undisturbed (2-kidney model). The rats in group 3, 4 and 5 underwent right nephrectomy 21 days before radiation (1-kidney model). Groups 1 and 3 received no drug treatment and served as controls for each model. Groups 2 and 4 had enalapril 50 mg/l in drinking water and group 5 hydrochlorothiazide (HCT) 200 mg/l, also in drinking water. Blood pressure increased significantly in both control groups and remained normal throughout the study in all treated groups. At the end of the study, mean urinary protein excretion was lower in the two enalapril-treated groups but not in HCT-treated animals. Groups 1 and 2 (2-kidney models) showed similar increments in plasma creatinine (PCreat), and, in both groups, the creatinine clearance (CCreat) dropped to the same extent. Among nephrectomized animals (1-kidney model), PCreat was lower and CCreat higher in the enalapril-treated group. Consistent with these findings, glomerular sclerosis was less severe in both enalapril-treated groups. We conclude that, in radiation nephritis, lowering blood pressure with enalapril exerts a beneficial effect on renal function and structure, whereas a similar reduction in blood pressure induced by HCT does not. |
| المشرفين على المادة: | 0J48LPH2TH (Hydrochlorothiazide) 69PN84IO1A (Enalapril) |
| تواريخ الأحداث: | Date Created: 19930101 Date Completed: 19930730 Latest Revision: 20180215 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1159/000187322 |
| PMID: | 8321359 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1660-8151 |
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| DOI: | 10.1159/000187322 |