دورية أكاديمية
[Biochemical characterization of fractionated rat liver chromatin in experimental D-hypovitaminosis and after administration of steroidal drugs].
| العنوان: | [Biochemical characterization of fractionated rat liver chromatin in experimental D-hypovitaminosis and after administration of steroidal drugs]. |
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| عنوان ترانسليتريتد: | Biokhimicheskie kharakteristiki fraktsionirovannogo khromatina pecheni krys v usloviiakh éksperimental'nogo D-gipovitaminoza i pri vvedenii preparatov steroidov. |
| المؤلفون: | Levitskiĭ EL, Kholodova IuD, Gubskiĭ IuI, Primak RG, Chabannyĭ VN, Kindruk NL, Mozzhukhina TG, Lenchevskaia LK, Mironova VN, Saad LM, et. al. |
| المصدر: | Ukrainskii biokhimicheskii zhurnal (1978) [Ukr Biokhim Zh (1978)] 1993 Jan-Feb; Vol. 65 (1), pp. 28-36. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Naukova Dumka Country of Publication: Ukraine NLM ID: 7804246 Publication Model: Print Cited Medium: Print ISSN: 0201-8470 (Print) Linking ISSN: 02018470 NLM ISO Abbreviation: Ukr Biokhim Zh (1978) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kiev : Izdatelstvo Naukova Dumka |
| مواضيع طبية MeSH: | Cholecalciferol/*pharmacology , Chromatin/*chemistry , Ecdysterone/*pharmacology , Liver/*chemistry , Vitamin D Deficiency/*metabolism, Animals ; Chemical Fractionation ; DNA-Directed DNA Polymerase/drug effects ; DNA-Directed DNA Polymerase/metabolism ; DNA-Directed RNA Polymerases/drug effects ; DNA-Directed RNA Polymerases/metabolism ; Lipid Peroxidation/drug effects ; Liver/drug effects ; Male ; Rats ; Rats, Wistar ; Structure-Activity Relationship ; Transcription, Genetic |
| مستخلص: | Marked changes in the structural and functional characteristics of liver nuclear chromatin fractions are observed under experimental D-hypovitaminosis, which differ in the degree of transcriptional activity. DNA-polymerase activity and activity of the fraction, enriched with RNA-polymerase I, increases in the active fraction. Free radical LPO reactions are modified in the chromatin fraction with low activity and to the less degree in the active one. Disturbances of chromatine structural properties are caused with the change in the protein and lipid components of chromatin. Administration of ecdysterone preparations (separately and together with vitamin D3) has a partial corrective effect on structural and functional organization of nuclear chromatine. At the action of ecdysterone normalization of LPO reactions modified by pathological changes is observed in the chromatin fraction with low activity and to the less degree in the active one. This kind of influence corrects to the less degree chromatin functional activity and quantitative and qualitative modifications of its protein component. Simultaneous influence of ecdysterone and vitamin D3 leads to the partial normalization of the biochemical indices studied (except for those which characterize LPO reactions) mainly in the active chromatin fraction. |
| المشرفين على المادة: | 0 (Chromatin) 1C6V77QF41 (Cholecalciferol) 5289-74-7 (Ecdysterone) EC 2.7.7.6 (DNA-Directed RNA Polymerases) EC 2.7.7.7 (DNA-Directed DNA Polymerase) |
| تواريخ الأحداث: | Date Created: 19930101 Date Completed: 19930914 Latest Revision: 20150505 |
| رمز التحديث: | 20221213 |
| PMID: | 8394607 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0201-8470 |
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