دورية أكاديمية
Hormonal control of proteins synthesized and secreted by guinea-pig endometrium.
| العنوان: | Hormonal control of proteins synthesized and secreted by guinea-pig endometrium. |
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| المؤلفون: | Abdi-Dezfuli F; Department of Pharmacology, University of Edinburgh Medical School, UK., Poyser NL |
| المصدر: | Journal of reproduction and fertility [J Reprod Fertil] 1993 Jan; Vol. 97 (1), pp. 179-88. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Portland Press Country of Publication: England NLM ID: 0376367 Publication Model: Print Cited Medium: Print ISSN: 0022-4251 (Print) Linking ISSN: 00224251 NLM ISO Abbreviation: J Reprod Fertil Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Colchester : Portland Press Original Publication: [Cambridge, Eng., etc.] Journals of Reproduction and Fertility Ltd. [etc.] |
| مواضيع طبية MeSH: | Protein Biosynthesis*, Endometrium/*metabolism , Estrus/*metabolism , Pregnancy, Animal/*metabolism, Animals ; Culture Techniques ; Endometrium/drug effects ; Estradiol/pharmacology ; Female ; Guinea Pigs ; Molecular Weight ; Ovariectomy ; Pregnancy ; Progesterone/pharmacology |
| مستخلص: | The amounts of protein synthesized and secreted (as indicated by [3H]leucine incorporation) by guinea-pig endometrium cultured for 24 h increased 2.1-fold between days 7 and 15 of the oestrous cycle. This increase did not occur if the guinea-pigs were pregnant. In ovariectomized guinea-pigs, oestradiol acting on a progesterone-primed uterus was the optimum stimulus for the maximum increase in endometrial protein synthesis and secretion. The two main proteins synthesized and secreted by day-15 guinea-pig endometrium had molecular masses of 99.8 and 192.1 kDa as determined on Sephacryl S-200HR. The production of the 99.8 kDa protein increased 5.2-fold between days 7 and 15 of the cycle. The 192.1 kDa protein was not detected in secretions produced by day 7 endometrium, and the 99.8 and 192.1 kDa proteins were not detected in secretions produced by day-15 pregnant endometrium. In ovariectomized guinea-pigs, progesterone did not stimulate the synthesis of secreted proteins of molecular masses above 77 kDa. Oestradiol stimulated the synthesis of secreted proteins with molecular masses of 87.8 and 192.1 kDa. However, oestradiol acting on a progesterone-primed uterus stimulated the synthesis of the secreted proteins with molecular masses of 99.8 and 192.1 kDa, which indicates that this combination of steroid hormones may be responsible for the increase in production of these two proteins by the day-15, nonpregnant guinea-pig endometrium. This stimulation by ovarian steroids of the synthesis and secretion of the 99.8 and 192.1 kDa proteins by the guinea-pig endometrium is apparently inhibited during early pregnancy. |
| المشرفين على المادة: | 4G7DS2Q64Y (Progesterone) 4TI98Z838E (Estradiol) |
| تواريخ الأحداث: | Date Created: 19930101 Date Completed: 19930503 Latest Revision: 20190724 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1530/jrf.0.0970179 |
| PMID: | 8464009 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-4251 |
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| DOI: | 10.1530/jrf.0.0970179 |