دورية أكاديمية
Blunted serotonergic responsivity in depressed inpatients.
| العنوان: | Blunted serotonergic responsivity in depressed inpatients. |
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| المؤلفون: | Mann JJ; Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA., McBride PA, Malone KM, DeMeo M, Keilp J |
| المصدر: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 1995 Aug; Vol. 13 (1), pp. 53-64. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print Cited Medium: Print ISSN: 0893-133X (Print) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : London : Nature Publishing Group Original Publication: [New York, NY] : Elsevier, [c1987- |
| مواضيع طبية MeSH: | Depression/*physiopathology , Neurons/*physiology , Serotonin/*metabolism, Administration, Oral ; Adult ; Age Factors ; Female ; Fenfluramine/pharmacology ; Humans ; Male ; Middle Aged ; Placebo Effect ; Prolactin/pharmacology ; Psychiatric Status Rating Scales ; Time Factors |
| مستخلص: | We found a 38% lower maximal prolactin response to an oral challenge dose of 60 mg of dl-fenfluramine relative to placebo in younger (< 30 years) depressed inpatients compared with the response in age-matched healthy controls (p < .03). Severity of depression did not correlate with prolactin response. Prolactin responses in older depressed patients (> or = 30 years) did not differ from older controls. Younger depressed patients differed from older depressed patients in terms of earlier age of onset of first lifetime episode of major depression, greater degree of suicidal intent during a recent suicide attempt, double the level of hopelessness on admission to hospital, and a higher rate of comorbid borderline personality disorder. A blunted prolactin response to fenfluramine may be interpreted as evidence for reduced serotonergic function in younger depressed patients and may underlie their observed greater suicidality and hopelessness. |
| معلومات مُعتمدة: | MH40695 United States MH NIMH NIH HHS; MH46745 United States MH NIMH NIH HHS |
| المشرفين على المادة: | 2DS058H2CF (Fenfluramine) 333DO1RDJY (Serotonin) 9002-62-4 (Prolactin) |
| تواريخ الأحداث: | Date Created: 19950801 Date Completed: 19960129 Latest Revision: 20150311 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/0893-133X(95)00016-7 |
| PMID: | 8526971 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0893-133X |
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| DOI: | 10.1016/0893-133X(95)00016-7 |