التفاصيل البيبلوغرافية
| العنوان: |
Predictive value of signs and symptoms for colorectal cancer in patients with rectal bleeding in general practice. |
| المؤلفون: |
Fijten GH; Diagnostic Coordination Centre, University Hospital, Maastricht, The Netherlands., Starmans R, Muris JW, Schouten HJ, Blijham GH, Knottnerus JA |
| المصدر: |
Family practice [Fam Pract] 1995 Sep; Vol. 12 (3), pp. 279-86. |
| نوع المنشور: |
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Oxford University Press Country of Publication: England NLM ID: 8500875 Publication Model: Print Cited Medium: Print ISSN: 0263-2136 (Print) Linking ISSN: 02632136 NLM ISO Abbreviation: Fam Pract Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Oxford : Oxford University Press, [c1983- |
| مواضيع طبية MeSH: |
Colorectal Neoplasms/*diagnosis , Gastrointestinal Hemorrhage/*etiology , Rectal Diseases/*etiology, Adolescent ; Adult ; Aged ; Colorectal Neoplasms/complications ; Cross-Sectional Studies ; Family Practice ; Female ; Follow-Up Studies ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Occult Blood ; Odds Ratio ; Predictive Value of Tests ; ROC Curve ; Sensitivity and Specificity |
| مستخلص: |
The aim of the study is to determine the diagnostic value of (combinations of) signs, symptoms and simple laboratory test results for colorectal cancer in patients with rectal bleeding presenting in general practice. Initial complaints and findings were compared with the final diagnoses based on clinical follow-up after at least 1 year. Patients studied were those presenting overt rectal bleeding to the general practitioner (83 GPs in the South of the Netherlands). Outcome measures are sensitivity, specificity, predictive values, odds ratios and a prediction model derived from multiple logistic regression analysis. Age, change in bowel habit and blood mixed with or on stool show a statistically significant independent value in the discrimination between patients with a low and those with a high probability of colorectal cancer. Many other variables did not show predictive value. The prediction model has a sensitivitiy of 100% and a specificity of 90%. Although the number of patients with colorectal cancer is small (n = 9) it was possible to identify three characteristics which can be helpful in the prediction of presence or absence of colorectal cancer in general practice. Application of the model presented might prevent 90% of 'unnecessary' invasive diagnostic procedures for patients with rectal bleeding who do not have colorectal cancer (true negative). Testing the performance of the model in other general practice populations is recommended. |
| تواريخ الأحداث: |
Date Created: 19950901 Date Completed: 19960208 Latest Revision: 20220330 |
| رمز التحديث: |
20240513 |
| DOI: |
10.1093/fampra/12.3.279 |
| PMID: |
8536830 |
| قاعدة البيانات: |
MEDLINE |
