دورية أكاديمية
Risk of breast cancer in a cohort of infertile women.
| العنوان: | Risk of breast cancer in a cohort of infertile women. |
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| المؤلفون: | Rossing MA; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Daling JR, Weiss NS, Moore DE, Self SG |
| المصدر: | Gynecologic oncology [Gynecol Oncol] 1996 Jan; Vol. 60 (1), pp. 3-7. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print Cited Medium: Print ISSN: 0090-8258 (Print) Linking ISSN: 00908258 NLM ISO Abbreviation: Gynecol Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Breast Neoplasms/*etiology , Infertility, Female/*complications, Adolescent ; Adult ; Breast Neoplasms/epidemiology ; Clomiphene/adverse effects ; Clomiphene/therapeutic use ; Cohort Studies ; Female ; Fertility Agents, Female/adverse effects ; Fertility Agents, Female/therapeutic use ; Humans ; Infertility, Female/drug therapy ; Infertility, Female/physiopathology ; Ovulation ; Risk Factors |
| مستخلص: | The purpose of this study was to assess: (1) the risk of breast cancer associated with use of ovulation-inducing agents (such as clomiphene citrate) as treatment for infertility; and (2) the risk associated with ovulatory abnormalities that result in infertility. We performed a case-cohort study among 3837 women evaluated for infertility at clinics in Seattle, Washington, at some time during 1974-1985. Computer linkage with a population-based tumor registry was used to identify women diagnosed with breast cancer before January 1, 1992. Data regarding infertility testing and treatment were abstracted from the infertility clinic medical records for women who developed breast cancer and a randomly selected subcohort. Twenty-seven women in the cohort developed in situ or invasive breast cancer, in comparison with an expected number of 28.8 cases (standardized incidence ratio, 0.9; 95% confidence interval (CI), ).6-1.4). Infertile women with evidence of an ovulatory abnormality were at a risk of breast cancer similar to that of women whose infertility was believed to be due to other causes. The risk among women who had taken clomiphene was reduced relative to infertile women who had not used this drug (adjusted relative risk, 0.5; 95% CI, 0.2-1.2), but the reduction in risk did not increase with duration of use. The possibility that use of clomiphene as treatment for infertility lowers the risk of breast cancer should be examined in other, larger studies. |
| التعليقات: | Comment in: Gynecol Oncol. 1996 Jan;60(1):1-2. (PMID: 8557219) |
| معلومات مُعتمدة: | N01-CN-05230 United States CN NCI NIH HHS; R35 CA 39779 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Fertility Agents, Female) 1HRS458QU2 (Clomiphene) |
| تواريخ الأحداث: | Date Created: 19960101 Date Completed: 19960223 Latest Revision: 20190825 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1006/gyno.1996.0002 |
| PMID: | 8557223 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0090-8258 |
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| DOI: | 10.1006/gyno.1996.0002 |