دورية أكاديمية
Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells.
| العنوان: | Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells. |
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| المؤلفون: | Panno ML; Dipartimento di Biologia Cellulare e Facoltà, di Farmacia, Università degli Studi della Calabria, Cosenza, Italy., Sisci D, Salerno M, Lanzino M, Mauro L, Morrone EG, Pezzi V, Palmero S, Fugassa E, Andò S |
| المصدر: | European journal of endocrinology [Eur J Endocrinol] 1996 May; Vol. 134 (5), pp. 633-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9423848 Publication Model: Print Cited Medium: Print ISSN: 0804-4643 (Print) Linking ISSN: 08044643 NLM ISO Abbreviation: Eur J Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Oxford : Oxford University Press Original Publication: Oslo, Norway : Scandinavian University Press, c1994- |
| مواضيع طبية MeSH: | Receptors, Estrogen/*metabolism , Sertoli Cells/*drug effects , Sertoli Cells/*metabolism , Triiodothyronine/*pharmacology, Animals ; Binding, Competitive ; Cell Nucleus/metabolism ; Cells, Cultured ; Cytosol/metabolism ; Diethylstilbestrol/metabolism ; Estradiol/metabolism ; Male ; Rats ; Rats, Wistar ; Sertoli Cells/ultrastructure ; Sexual Maturation ; Testis/drug effects ; Testis/growth & development ; Testosterone/pharmacology |
| مستخلص: | The effects of thyroid hormone on androgen metabolism in peripuberal Sertoli cells through the inhibition of estradiol production have been reported previously. It was our intention to investigate further the possible role of thyroid hormone on the interaction between testicular steroids and Sertoli cells by analyzing the effects of triiodothyronine (T3) on estrogen receptor content in 2-, 3- and 4- week-old euthyroid rats. Triiodothyronine treatment (3 micrograms/100 body wt per day) given during the last week prior to sacrifice resulted in reduced testicular growth in 2-week-old animals. Sertoli cells from all groups were cultured initially under basal conditions for the first 24 h and subsequently in the presence of testosterone and/or T3 for the additional 24 h. The in vitro addition of T3 induced a decrease of estrogen receptors (ERs) in 2- and 3-week-old animals that appeared more pronounced especially in the presence of T3 and testosterone. When T3 was tested in vivo we noticed that the decrease of ER content was even greater in all three groups under the in vitro influence of both T3 and testosterone. In 3-week-old animals a simultaneous assay of ERs in both nuclear and cytoplasmic compartments was performed. The ER concentrations in the nucleus were closely related to those of the cytoplasm. The in vivo administration of T3 was responsible for a greater decrease of ERs in the nucleus than in the cytosol. On the basis of these results, and in agreement with our previous data, we speculate that the effect of T3 in the maturational events of Sertoli cells could involve both estradiol production and ER content. |
| المشرفين على المادة: | 0 (Receptors, Estrogen) 06LU7C9H1V (Triiodothyronine) 3XMK78S47O (Testosterone) 4TI98Z838E (Estradiol) 731DCA35BT (Diethylstilbestrol) |
| تواريخ الأحداث: | Date Created: 19960501 Date Completed: 19960808 Latest Revision: 20190905 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1530/eje.0.1340633 |
| PMID: | 8664985 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0804-4643 |
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| DOI: | 10.1530/eje.0.1340633 |