دورية أكاديمية
CWR22: the first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar.
| العنوان: | CWR22: the first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar. |
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| المؤلفون: | Nagabhushan M; Department of Pathology, Case Western Reserve University Medical Center, Cleveland, Ohio 44106, USA., Miller CM, Pretlow TP, Giaconia JM, Edgehouse NL, Schwartz S, Kung HJ, de Vere White RW, Gumerlock PH, Resnick MI, Amini SB, Pretlow TG |
| المصدر: | Cancer research [Cancer Res] 1996 Jul 01; Vol. 56 (13), pp. 3042-6. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Print ISSN: 0008-5472 (Print) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Baltimore, Md. : American Association for Cancer Research Original Publication: Chicago [etc.] |
| مواضيع طبية MeSH: | Androgens*, Neoplasms, Hormone-Dependent/*pathology , Prostatic Neoplasms/*pathology, Agar ; Animals ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Neoplasms, Hormone-Dependent/blood ; Orchiectomy ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Testosterone/pharmacology ; Transplantation, Heterologous ; Tumor Cells, Cultured |
| مستخلص: | Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and relapse less than 5 weeks after androgen withdrawal. After androgen withdrawal, the human primary prostate cancer xenograft CWR22 regresses markedly, and prostate-specific antigen (PSA) falls up to 3000-fold in the blood of mice. PSA usually returns to normal. In some animals, the tumor relapses and is then designated CWR22R. In these animals, PSA starts to rise approximately 2-7 months, and tumor begins to grow 3-10 months after castration. Animals with CWR22 need to be euthanized because of large tumors 6-12 weeks after the transplantation of CWR22. Androgen withdrawal prolongs life approximately 3-4-fold. |
| معلومات مُعتمدة: | CA 57179 United States CA NCI NIH HHS; DK 45770 United States DK NIDDK NIH HHS; DK 51347 United States DK NIDDK NIH HHS; etc. |
| المشرفين على المادة: | 0 (Androgens) 3XMK78S47O (Testosterone) 9002-18-0 (Agar) EC 3.4.21.77 (Prostate-Specific Antigen) |
| تواريخ الأحداث: | Date Created: 19960701 Date Completed: 19960812 Latest Revision: 20220310 |
| رمز التحديث: | 20221213 |
| PMID: | 8674060 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0008-5472 |
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