دورية أكاديمية
Novel hypotheses for the roles of EBNA-1 and BHRF1 in EBV-related cancers.
| العنوان: | Novel hypotheses for the roles of EBNA-1 and BHRF1 in EBV-related cancers. |
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| المؤلفون: | Horner D; Ludwig Institute for Cancer Research, St. Mary's Hospital Medical School, London, UK., Lewis M, Farrell PJ |
| المصدر: | Intervirology [Intervirology] 1995; Vol. 38 (3-4), pp. 195-205. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0364265 Publication Model: Print Cited Medium: Print ISSN: 0300-5526 (Print) Linking ISSN: 03005526 NLM ISO Abbreviation: Intervirology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Karger. |
| مواضيع طبية MeSH: | Antigens, Viral/*genetics , Burkitt Lymphoma/*virology , DNA-Binding Proteins/*genetics , Herpesvirus 4, Human/*chemistry , Herpesvirus 4, Human/*genetics , Nasopharyngeal Neoplasms/*virology , Tumor Virus Infections/*virology , Viral Proteins/*genetics, Apoptosis ; Base Sequence ; Binding Sites ; Carcinoma/virology ; Epstein-Barr Virus Nuclear Antigens ; Gene Expression ; Genes, Viral ; Genome, Viral ; Leukoplakia, Hairy/virology ; Molecular Sequence Data ; Transcriptional Activation |
| مستخلص: | Epstein-Barr virus has been linked to several types of human cancer including Burkitt's lymphoma and nasopharyngeal carcinoma but the mechanisms by which the virus might contribute to cancer remain obscure. Here we consider the possibility that EBNA-1, which is expressed in both tumours, directly transactivates cell genes. The EBNA-1 protein was tested for transcription transactivation domains and the human genome was screened for high-affinity EBNA-1-binding sites that might mediate transactivation. None were found, although novel low-affinity-binding sites in the EBV genome were detected. We also investigated the expression of BHRF1, the viral homologue to bcl-2, in epithelial cells and showed that it is expressed in vivo in the EBV replication found in oral hairy leukoplakia. A novel hypothesis is proposed for nasopharyngeal carcinoma in which BHRF1 expression protects cells against apoptotic death caused by environmental DNA damaging agents and thus contributes to the early stages of cancer development. |
| المشرفين على المادة: | 0 (Antigens, Viral) 0 (BHRF1 protein, Human herpesvirus 4) 0 (DNA-Binding Proteins) 0 (Epstein-Barr Virus Nuclear Antigens) 0 (Viral Proteins) |
| تواريخ الأحداث: | Date Created: 19950101 Date Completed: 19960820 Latest Revision: 20180215 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1159/000150433 |
| PMID: | 8682617 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0300-5526 |
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| DOI: | 10.1159/000150433 |