دورية أكاديمية
Effects of antiinflammatory agents on the acute response of immune synovitis in rabbits.
| العنوان: | Effects of antiinflammatory agents on the acute response of immune synovitis in rabbits. |
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| المؤلفون: | Goldlust MB, Rich LC, Harrity TW |
| المصدر: | Arthritis and rheumatism [Arthritis Rheum] 1977 May; Vol. 20 (4), pp. 937-46. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0370605 Publication Model: Print Cited Medium: Print ISSN: 0004-3591 (Print) Linking ISSN: 00043591 NLM ISO Abbreviation: Arthritis Rheum Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Atlanta [etc.] Arthritis Foundation [etc.] |
| مواضيع طبية MeSH: | Disease Models, Animal*, Anti-Inflammatory Agents/*therapeutic use , Synovitis/*drug therapy, Animals ; Aspirin/therapeutic use ; Colchicine/therapeutic use ; Dose-Response Relationship, Immunologic ; Glucuronidase/metabolism ; Indomethacin/therapeutic use ; Lysosomes/enzymology ; Methods ; Niflumic Acid/therapeutic use ; Phenylbutazone/therapeutic use ; Prednisolone/therapeutic use ; Rabbits ; Serum Albumin, Bovine/immunology ; Triamcinolone Acetonide/therapeutic use |
| مستخلص: | Immune synovitis in rabbits was investigated as a potential in vivo model for evaluating new antiinflammatory agents. Antigen-induced increases in knee width as well as beta-glucuronidase and acid phosphatase activities in exudates were observed. Histologically, polymorphonuclear leukocytes appeared within hours in synovial tissues and reached maximum infiltration at about 24 hours. Subsequently, mononuclear cells, including plasma cells, appeared. The 6-hour Arthus-like phase of synovitis can be depressed by some antiinflammatory agents, colchicine and steroids being particularly effective. It is suggested that this model can be utilized to define potentially more effective antiinflammatory drugs. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 27432CM55Q (Serum Albumin, Bovine) 4U5MP5IUD8 (Niflumic Acid) 9PHQ9Y1OLM (Prednisolone) EC 3.2.1.31 (Glucuronidase) F446C597KA (Triamcinolone Acetonide) GN5P7K3T8S (Phenylbutazone) R16CO5Y76E (Aspirin) SML2Y3J35T (Colchicine) XXE1CET956 (Indomethacin) |
| تواريخ الأحداث: | Date Created: 19770501 Date Completed: 19770630 Latest Revision: 20190717 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/art.1780200406 |
| PMID: | 871302 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0004-3591 |
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| DOI: | 10.1002/art.1780200406 |