دورية أكاديمية
The reaction between nitric oxide and alpha-tocopherol: a reappraisal.
| العنوان: | The reaction between nitric oxide and alpha-tocopherol: a reappraisal. |
|---|---|
| المؤلفون: | Hogg N; Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226, USA., Singh RJ, Goss SP, Kalyanaraman B |
| المصدر: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1996 Jul 25; Vol. 224 (3), pp. 696-702. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print Cited Medium: Print ISSN: 0006-291X (Print) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002- >: San Diego, CA : Elsevier Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Nitric Oxide/*chemistry , Vitamin E/*chemistry, Free Radicals ; Oxidation-Reduction ; Oxygen/chemistry ; Vitamin E/analogs & derivatives |
| مستخلص: | Recently Gorbunov et al. reported that nitric oxide (.NO) can directly oxidize alpha-tocopherol to alpha-tocopheroxyl radical (Gorbunov et al., Biochem. Biophys. Res. Commun., 219, 835-841, 1996). We have reinvestigated this reaction and report that a direct reaction between .NO and alpha-tocopherol does not occur. However, the reaction between .NO and oxygen generates an oxidant which oxidizes alpha-tocopherol to alpha-tocopheryl quinone. Exposure of alpha-tocopherol to a low flux of .NO generated from spermine NONOate (100 microM) results in no consumption of alpha-tocopherol under either aerobic or anaerobic conditions. A higher flux of .NO, generated from 1 mM spermine NONOate, oxidizes alpha-tocopherol only under aerobic conditions. Artifactual oxidation of alpha-tocopherol can be observed when using commercial .NO that is contaminated with higher oxides of nitrogen, such as dinitrogen trioxide and dinitrogen tetraoxide. |
| معلومات مُعتمدة: | HL47250 United States HL NHLBI NIH HHS; RR01008 United States RR NCRR NIH HHS |
| المشرفين على المادة: | 0 (Free Radicals) 1406-18-4 (Vitamin E) 31C4KY9ESH (Nitric Oxide) 7559-04-8 (tocopherylquinone) S88TT14065 (Oxygen) |
| تواريخ الأحداث: | Date Created: 19960725 Date Completed: 19960910 Latest Revision: 20220311 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1006/bbrc.1996.1086 |
| PMID: | 8713109 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0006-291X |
|---|---|
| DOI: | 10.1006/bbrc.1996.1086 |