دورية أكاديمية
أعرض في EDS

Effects of brain ischemia on intermediate filaments of rat hippocampus.

التفاصيل البيبلوغرافية
العنوان: Effects of brain ischemia on intermediate filaments of rat hippocampus.
المؤلفون: Camargo-De-Morais M; Departamento de Bioquímica, IB--UFRGS (Campus Central), Porto Alegre, RS, Brazil., De Freitas M, De Mattos AG, Schröder N, Zilles AC, Lisboa CS, Arteni N, Barlem A, Schierholt R, Zwetsch G, Souza CA, Pessoa-Pureur R, Netto CA
المصدر: Neurochemical research [Neurochem Res] 1996 May; Vol. 21 (5), pp. 595-602.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Print Cited Medium: Print ISSN: 0364-3190 (Print) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press
مواضيع طبية MeSH: Glial Fibrillary Acidic Protein/*biosynthesis , Hippocampus/*metabolism , Ischemic Attack, Transient/*metabolism , Neurofilament Proteins/*metabolism, Animals ; Carbon Radioisotopes ; Cytoskeletal Proteins/metabolism ; Kinetics ; Leucine/metabolism ; Phosphorus Radioisotopes ; Radioisotope Dilution Technique ; Rats ; Rats, Wistar ; Reperfusion ; Time Factors
مستخلص: Neurofilaments subunits (NF-H, NF-M, NF-L) and glial fibrillary acidic protein (GFAP) were investigated in the hippocampus of rats after distinct periods of reperfusion (1 to 15 days) following 20 min of transient global forebrain ischemia in the rat. In vitro [14Ca]leucine incorporation was not altered until 48 h after the ischemic insult, however concentration of intermediate filament subunits significantly decreased in this period. Three days after the insult, leucine incorporation significantly increased while the concentration NF-H, NF-M, and NF-L were still diminished after 15 days of reperfusion. In vitro incorporation of 32P into NF-M and NF-L suffered immediately after ischemia, but returned to control values after two days of reperfusion. GFAP levels decreased immediately after ischemia but quickly recovered and significantly peaked from 7 to 10 days after the insult. These results suggest that transient ischemia followed by reperfusion causes proteolysis of intermediate filaments in the hippocampus, and the proteolysis could be facilitated by diminished phosphorylation levels of NF-M and NF-L.
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المشرفين على المادة: 0 (Carbon Radioisotopes)
0 (Cytoskeletal Proteins)
0 (Glial Fibrillary Acidic Protein)
0 (Neurofilament Proteins)
0 (Phosphorus Radioisotopes)
0 (neurofilament protein L)
108688-71-7 (neurofilament protein H)
111365-29-8 (neurofilament protein M)
GMW67QNF9C (Leucine)
تواريخ الأحداث: Date Created: 19960501 Date Completed: 19961107 Latest Revision: 20190821
رمز التحديث: 20231215
DOI: 10.1007/BF02527758
PMID: 8726968
قاعدة البيانات: MEDLINE
الوصف
تدمد:0364-3190
DOI:10.1007/BF02527758