دورية أكاديمية
beta-lactam antibiotics in the treatment of neuroborreliosis in children: preliminary results.
| العنوان: | beta-lactam antibiotics in the treatment of neuroborreliosis in children: preliminary results. |
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| المؤلفون: | Millner MM; Universitätskinderklinik Graz, Arbeitsgruppe Kinderneuropsychiatrie, Austria., Thalhammer GH, Dittrich P, Spork KD, Brunner M, Georgopoulos A |
| المصدر: | Infection [Infection] 1996 Mar-Apr; Vol. 24 (2), pp. 174-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 0365307 Publication Model: Print Cited Medium: Print ISSN: 0300-8126 (Print) Linking ISSN: 03008126 NLM ISO Abbreviation: Infection Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Heidelberg : Springer Heidelberg Original Publication: München, Verlagsgesellschaft Otto Spatz. |
| مواضيع طبية MeSH: | Ceftriaxone/*pharmacokinetics , Cephalosporins/*pharmacokinetics , Lyme Disease/*drug therapy , Penicillin G/*pharmacokinetics , Penicillins/*pharmacokinetics, Adolescent ; Ceftriaxone/blood ; Ceftriaxone/cerebrospinal fluid ; Cephalosporins/blood ; Cephalosporins/cerebrospinal fluid ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Lyme Disease/blood ; Lyme Disease/cerebrospinal fluid ; Male ; Nervous System Diseases/microbiology ; Penicillin G/blood ; Penicillin G/cerebrospinal fluid ; Penicillins/blood ; Penicillins/cerebrospinal fluid ; Time Factors |
| مستخلص: | In vitro beta-lactam antibiotics like ceftriaxone and penicillin G sodium have been shown to be active against Borrelia burgdorferi. Results of quantitative determinations of both antibiotic substances in the CSF for children are limited. Seventy-five children (median age 96 months, range 10 to 176 months) with probable or definite neuroborreliosis were treated with ceftriaxone (1 x 50-90 mg/kg/day) or penicillin G sodium (4 x 80,000-120,000 IU/kg/day) intravenously. On day 10 of therapy levels of penicillin G sodium (1,1.5,2,3,4, 5, or 6 h after i.v. administration), and ceftriaxone (1,2,4,6,12 or 24 h after i.v. administration) in serum and CSF were measured with a micro agar diffusion bioassay. Results demonstrate that after 5 h penicillin G sodium in CSF was above the minimal inhibitory concentration (MIC) but after 6 h penicillin G sodium levels were below the determination limit in 60% of the cases. All ceftriaxone results in CSF-even after 24 h-were above MIC. Penicillin G sodium serum values ranged from 46.6 to 0.1 mg/L (1 to 6 h post dose) and ceftriaxone serum values from 261 to 5 mg/l (1 to 24 h post dose). The role of penicillin G sodium and ceftriaxone and administration intervals of both antibiotics in the therapy of neuroborreliosis in children are discussed. |
| References: | J Pharmacol Exp Ther. 1986 Feb;236(2):380-3. (PMID: 3080583) J Pediatr. 1984 Sep;105(3):475-81. (PMID: 6088747) J Am Acad Dermatol. 1985 Sep;13(3):444-9. (PMID: 3902917) Antimicrob Agents Chemother. 1987 Mar;31(3):385-8. (PMID: 3579254) Antimicrob Agents Chemother. 1987 Feb;31(2):164-7. (PMID: 3566246) Infection. 1991 Jul-Aug;19(4):273-8. (PMID: 1917045) Ann N Y Acad Sci. 1988;539:93-102. (PMID: 3263829) J Pharmacobiodyn. 1989 Mar;12(3):182-5. (PMID: 2760797) Yale J Biol Med. 1984 Jul-Aug;57(4):549-53. (PMID: 6516457) Chemotherapy. 1990;36(6):441-7. (PMID: 2292206) Sci Am. 1989 Nov;261(5):68-74. (PMID: 2479097) J Pharmacol Exp Ther. 1987 Aug;242(2):660-5. (PMID: 3612557) J Neurol. 1980;224(2):89-99. (PMID: 6160221) Eur J Clin Microbiol. 1987 Aug;6(4):424-6. (PMID: 3665899) J Infect Dis. 1987 Jul;156(1):209-11. (PMID: 3110304) Infection. 1994 Nov-Dec;22(6):401-6. (PMID: 7698837) Zentralbl Bakteriol Orig A. 1978;242(3):387-93. (PMID: 106581) J Pharmacol Exp Ther. 1989 Jul;250(1):324-8. (PMID: 2746505) Clin Pharmacol Ther. 1985 May;37(5):522-8. (PMID: 3987175) Zentralbl Bakteriol Mikrobiol Hyg A. 1986 Dec;263(1-2):112-8. (PMID: 3577473) |
| المشرفين على المادة: | 0 (Cephalosporins) 0 (Penicillins) 75J73V1629 (Ceftriaxone) Q42T66VG0C (Penicillin G) |
| تواريخ الأحداث: | Date Created: 19960301 Date Completed: 19961112 Latest Revision: 20190830 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1007/BF01713334 |
| PMID: | 8740117 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0300-8126 |
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| DOI: | 10.1007/BF01713334 |