دورية أكاديمية
Graft failure after donor leucocyte infusion in relapsed chronic myeloid leukaemia: successful treatment with cyclophosphamide and antithymocyte globulin followed by peripheral blood stem cell infusion.
| العنوان: | Graft failure after donor leucocyte infusion in relapsed chronic myeloid leukaemia: successful treatment with cyclophosphamide and antithymocyte globulin followed by peripheral blood stem cell infusion. |
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| المؤلفون: | Keil F; Department of Medicine I, University of Vienna, Austria., Kalhs P, Haas OA, Fritsch G, Mitterbauer G, Brugger S, Lechner K, Schwarzinger I, Mannhalter C, Linkesch W, Kurz M, Greinix HT |
| المصدر: | British journal of haematology [Br J Haematol] 1996 Jul; Vol. 94 (1), pp. 120-2. |
| نوع المنشور: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print Cited Medium: Print ISSN: 0007-1048 (Print) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Graft Rejection* , Leukocyte Transfusion*, Antilymphocyte Serum/*therapeutic use , Cyclophosphamide/*therapeutic use , Graft vs Host Disease/*therapy , Immunosuppressive Agents/*therapeutic use , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*therapy, Fusion Proteins, bcr-abl/analysis ; Humans ; Male ; Middle Aged ; Recurrence ; Stem Cell Transplantation ; Transplantation Chimera |
| مستخلص: | We report a patient with chronic myeloid leukaemia who underwent allogeneic marrow transplantation (BMT) but had a molecular relapse 5 months and haematological relapse 15 months after BMT. Since therapy with alpha-interferon had been ineffective he received leucocyte infusions from his sibling donor. He developed acute graft-versus-host disease and became aplastic 6 weeks later. Despite donor marrow infusion and cytokine stimulation marrow aplasia persisted for 13 weeks. Then, donors' peripheral blood stem cells were given after conditioning with cyclophosphamide and antithymocyte globulin resulting in trilineage engraftment of donor haemopoiesis. Since then, the patient has been in continuous molecular remission for 11 months. |
| المشرفين على المادة: | 0 (Antilymphocyte Serum) 0 (Immunosuppressive Agents) 8N3DW7272P (Cyclophosphamide) EC 2.7.10.2 (Fusion Proteins, bcr-abl) |
| تواريخ الأحداث: | Date Created: 19960701 Date Completed: 19960926 Latest Revision: 20190705 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1046/j.1365-2141.1996.d01-1770.x |
| PMID: | 8757519 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0007-1048 |
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| DOI: | 10.1046/j.1365-2141.1996.d01-1770.x |