دورية أكاديمية
Trough:peak ratio of nifedipine gastrointestinal therapeutic system and nifedipine retard in essential hypertensive patients: an Italian multicentre study.
| العنوان: | Trough:peak ratio of nifedipine gastrointestinal therapeutic system and nifedipine retard in essential hypertensive patients: an Italian multicentre study. |
|---|---|
| المؤلفون: | Salvetti A; Clinica Medica I, University of Pisa, Italy., Virdis A, Taddei S, Ambrosoli S, Caiazza A, Gandolfi E, del Prato C, Saba G, nello Ceccarelli C, Buoninconti R, Spadari G, Kilama MO |
| المصدر: | Journal of hypertension [J Hypertens] 1996 May; Vol. 14 (5), pp. 661-7. |
| نوع المنشور: | Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, Inc Country of Publication: England NLM ID: 8306882 Publication Model: Print Cited Medium: Print ISSN: 0263-6352 (Print) Linking ISSN: 02636352 NLM ISO Abbreviation: J Hypertens Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Alphen aan den Rijn, the Netherlands] : Wolters Kluwer Health, Inc. Original Publication: London ; New York : Gower Academic Pub., [1983- |
| مواضيع طبية MeSH: | Calcium Channel Blockers/*administration & dosage , Hypertension/*drug therapy , Nifedipine/*administration & dosage, Adult ; Aged ; Blood Pressure/drug effects ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Nifedipine/pharmacokinetics |
| مستخلص: | Objective: To evaluate the antihypertensive effect of nifedipine gastrointestinal therapeutic system and retard in terms of trough:peak ratio efficacy. Methods: According to a double-blind, randomized, crossover design, 58 patients with mild-to-moderate essential hypertension, after 1 month placebo washout, received 30 mg/day nifedipine gastrointestinal therapeutic system, 20 mg nifedipine retard twice a day and the corresponding placebos for 1 month. At the end of each treatment period, blood pressure was measured by using a mercury sphygmomanometer at trough and 1, 2, 3 and 4 h after the last dosing. The peak effect was identified as the maximum decrement induced by the three randomized treatments with respect to the value at the end of the placebo washout period during the 4 h interval. The trough:peak ratios of systolic and diastolic blood pressure were calculated as group ratios and individual ratios from decrements induced by nifedipine gastrointestinal therapeutic system and retard, corrected for those induced by randomized placebo. Patients were defined as responders to each randomized treatment if their diastolic blood pressure at trough time was reduced by at least 10 mmHg relative to that at the corresponding time at the end of placebo washout. Results: Nifedipine gastrointestinal therapeutic system and retard significantly reduced blood pressure to a similar extent both at trough and at peak. Systolic and diastolic group trough:peak ratios in responders to nifedipine gastrointestinal therapeutic system (n = 41) were 0.80 and 0.88, respectively, and those in responders to nifedipine retard (n = 30) 0.84 and 0.93, respectively. The percentage of patients with trough:peak ratios > 0.50 was > 80% (systolic trough:peak ratios) and above 90% (diastolic trough: peak ratios) for both nifedipine formulations. Conclusions: Our data show that 30 mg/day nifedipine gastrointestinal therapeutic system and 20 mg nifedipine retard twice a day have a favourable trough:peak ratios efficacy when given as monotherapy to essential hypertensive patients. |
| المشرفين على المادة: | 0 (Calcium Channel Blockers) I9ZF7L6G2L (Nifedipine) |
| تواريخ الأحداث: | Date Created: 19960501 Date Completed: 19961024 Latest Revision: 20190821 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/00004872-199605000-00017 |
| PMID: | 8762211 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0263-6352 |
|---|---|
| DOI: | 10.1097/00004872-199605000-00017 |