دورية أكاديمية
Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.
| العنوان: | Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. |
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| المؤلفون: | Rath HC; Center of Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill 27599-7080, USA., Herfarth HH, Ikeda JS, Grenther WB, Hamm TE Jr, Balish E, Taurog JD, Hammer RE, Wilson KH, Sartor RB |
| المصدر: | The Journal of clinical investigation [J Clin Invest] 1996 Aug 15; Vol. 98 (4), pp. 945-53. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Print ISSN: 0021-9738 (Print) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation Original Publication: New Haven [etc.] American Society for Clinical Investigation. |
| مواضيع طبية MeSH: | Arthritis/*microbiology , Bacteroides/*pathogenicity , Colitis/*microbiology , Gastritis/*microbiology , HLA-B27 Antigen/*immunology, Animals ; Animals, Genetically Modified ; Base Sequence ; Chronic Disease ; Cytokines/genetics ; DNA Primers/chemistry ; Digestive System/microbiology ; Gene Expression ; Humans ; Molecular Sequence Data ; RNA, Messenger/genetics ; Rats ; beta 2-Microglobulin/immunology |
| مستخلص: | Genetic and environmental factors are important in the pathogenesis of clinical and experimental chronic intestinal inflammation. We investigated the influence of normal luminal bacteria and several groups of selected bacterial strains on spontaneous gastrointestinal and systemic inflammation in HLA-B27 transgenic rats. Rats maintained germfree for 3-9 mo were compared with littermates conventionalized with specific pathogen-free bacteria. Subsequently, germfree transgenic rats were colonized with groups of five to eight bacteria that were either facultative or strictly anaerobic. Transgenic germfree rats had no gastroduodenitis, colitis, or arthritis, but developed epididymitis and dermatitis to the same degree as conventionalized rats. Colonic proinflammatory cytokine expression was increased in transgenic conventionalized rats but was undetectable in germfree and nontransgenic rats. Colitis progressively increased over the first 4 wk of bacterial exposure, then plateaued. Only transgenic rats colonized with defined bacterial cocktails which contained Bacteroides spp. had colitis and gastritis. Normal luminal bacteria predictably and uniformly induce chronic colonic, gastric and systemic inflammation in B27 transgenic F344 rats, but all bacterial species do not have equal activities. |
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| معلومات مُعتمدة: | AR 38319 United States AR NIAMS NIH HHS; DK 34989 United States DK NIDDK NIH HHS; DK 40249 United States DK NIDDK NIH HHS |
| المشرفين على المادة: | 0 (Cytokines) 0 (DNA Primers) 0 (HLA-B27 Antigen) 0 (RNA, Messenger) 0 (beta 2-Microglobulin) |
| تواريخ الأحداث: | Date Created: 19960815 Date Completed: 19961010 Latest Revision: 20220309 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC507509 |
| DOI: | 10.1172/JCI118878 |
| PMID: | 8770866 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0021-9738 |
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| DOI: | 10.1172/JCI118878 |