دورية أكاديمية
Only four days of quadruple therapy can effectively cure Helicobacter pylori infection.
| العنوان: | Only four days of quadruple therapy can effectively cure Helicobacter pylori infection. |
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| المؤلفون: | De Boer WA; Department of Internal Medicine, Sint Joseph Hospital, Veldhoven, Netherlands., Driessen WM, Tytgat GN |
| المصدر: | Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 1995 Dec; Vol. 9 (6), pp. 633-8. |
| نوع المنشور: | Clinical Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8707234 Publication Model: Print Cited Medium: Print ISSN: 0269-2813 (Print) Linking ISSN: 02692813 NLM ISO Abbreviation: Aliment Pharmacol Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: [Oxford, OX] : Blackwell Scientific Publications, [c1987- |
| مواضيع طبية MeSH: | Helicobacter pylori*, Antacids/*therapeutic use , Anti-Bacterial Agents/*therapeutic use , Anti-Ulcer Agents/*therapeutic use , Helicobacter Infections/*drug therapy , Peptic Ulcer/*drug therapy, Adult ; Aged ; Aged, 80 and over ; Bismuth/therapeutic use ; Drug Therapy, Combination ; Dyspepsia/drug therapy ; Female ; Gastroscopy ; Humans ; Male ; Metronidazole/therapeutic use ; Middle Aged ; Omeprazole/therapeutic use ; Tetracycline/therapeutic use |
| مستخلص: | Aim: To determine whether 4 days of quadruple therapy using bismuth, tetracycline and metronidazole combined with omeprazole is effective treatment for Helicobacter pylori infection. Methods: Non-ulcer dyspepsia, as well as chronic peptic ulcer patients with biopsy-proven H. pylori infection received 4 days of quadruple therapy. They were pretreated with 3 days of omeprazole. At least 5-6 weeks later, endoscopy was repeated with 10 biopsies for urease test, histology and culture to establish cure of infection. Results: None of the 54 patients included was lost to follow-up but two had a 14C-urea breath test instead of endoscopy. Side-effects did not interfere with compliance. Forty-nine out of 54 patients (91%; 95% CI: 80-97%) were cured. Metronidazole susceptibility data were available from 43 pre-treatment isolates. Of these 38/40 (95%) with a metronidazole-sensitive strain, and one of three with a metronidazole-resistant strain were cured. Conclusions: Four days of quadruple therapy after omeprazole pre-treatment is a feasible, well tolerated, and effective treatment for H. pylori infection, especially in those carrying a metronidazole-sensitive strain. It seems that in quadruple therapy, cure rate and treatment duration have a non-linear relation. Our results need confirmation, but for patients suffering from side-effects with the 7-day regimen stopping treatment after 4 days is justified. |
| المشرفين على المادة: | 0 (Antacids) 0 (Anti-Bacterial Agents) 0 (Anti-Ulcer Agents) 140QMO216E (Metronidazole) F8VB5M810T (Tetracycline) KG60484QX9 (Omeprazole) U015TT5I8H (Bismuth) |
| تواريخ الأحداث: | Date Created: 19951201 Date Completed: 19961112 Latest Revision: 20190830 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1365-2036.1995.tb00432.x |
| PMID: | 8824650 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0269-2813 |
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| DOI: | 10.1111/j.1365-2036.1995.tb00432.x |