دورية أكاديمية
PCDDs, PCDFs, and PCBs in human blood in relation to consumption of crabs from a contaminated Fjord area in Norway.
| العنوان: | PCDDs, PCDFs, and PCBs in human blood in relation to consumption of crabs from a contaminated Fjord area in Norway. |
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| المؤلفون: | Johansen HR; Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway., Alexander J, Rossland OJ, Planting S, Løvik M, Gaarder PI, Gdynia W, Bjerve KS, Becher G |
| المصدر: | Environmental health perspectives [Environ Health Perspect] 1996 Jul; Vol. 104 (7), pp. 756-64. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences. |
| مواضيع طبية MeSH: | Food Contamination*, Brachyura/*chemistry , Hydrocarbons, Chlorinated/*blood , Pesticide Residues/*blood , Water Pollutants, Chemical/*blood, Adult ; Animals ; Benzofurans/blood ; Body Burden ; Case-Control Studies ; Fishes/metabolism ; Humans ; Male ; Middle Aged ; Norway ; Polychlorinated Biphenyls/blood ; Polychlorinated Dibenzodioxins/analogs & derivatives ; Polychlorinated Dibenzodioxins/blood |
| مستخلص: | Consumption of fish and shellfish from contaminated areas may be an important source of human exposure to persistent organohalogen compounds such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs). We determined concentrations of 2,3,7,8-substituted PCDDs and PCDFs and 19 PCB congeners in whole blood samples from three groups of men, 40-54 years of age, with different consumption levels of crabs from a fjord area in southern Norway polluted with organochlorine compounds from a magnesium production plant. A significant increase of many PCDD/PCDF congeners was found in the blood when comparing the referents, moderate-, and high-intake groups. The greatest difference was observed for several of the PCDFs that are characteristic for the contamination of the marine biota of the fjord. PCBs, in general, play a minor role in the contamination of the fjord by the magnesium production process, except for the highly chlorinated congeners such as PCB-209. Nevertheless, almost all PCBs increased from the referents to the high-intake group. However, the relative concentrations of several highly chlorinated PCBs (particularly PCB-209) in blood are unexpectedly low compared to their abundance in crabs, indicating low uptake of these congeners. The exposure to PCDDs/PCDFs from crab consumption calculated from individual body burdens of these compounds were in good agreement with the intake estimated from previously measured concentrations in crabs, reported fishing sites, and consumption. Almost all subjects in the high-intake group exceeded the tolerable weekly intake of 35 pg TEQ/kg body weight/week proposed by a Nordic Expert Group. |
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| المشرفين على المادة: | 0 (Benzofurans) 0 (Hydrocarbons, Chlorinated) 0 (Pesticide Residues) 0 (Polychlorinated Dibenzodioxins) 0 (Water Pollutants, Chemical) DFC2HB4I0K (Polychlorinated Biphenyls) |
| تواريخ الأحداث: | Date Created: 19960701 Date Completed: 19970102 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC1469397 |
| DOI: | 10.1289/ehp.96104756 |
| PMID: | 8841762 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0091-6765 |
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| DOI: | 10.1289/ehp.96104756 |