دورية أكاديمية
AR4-2J cell line coexpresses dihydropyridine and omega-conotoxin sensitive Ca2+ channels.
| العنوان: | AR4-2J cell line coexpresses dihydropyridine and omega-conotoxin sensitive Ca2+ channels. |
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| المؤلفون: | Bertrand V; INSERM U 151, Institut Fédératif de Recherches Louis Bugnard, CHU Rangueil, Toulouse, France., Bastié MJ, Bouisson M, Vaysse N, Pradayrol L |
| المصدر: | Cell calcium [Cell Calcium] 1996 Jun; Vol. 19 (6), pp. 495-500. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006226 Publication Model: Print Cited Medium: Print ISSN: 0143-4160 (Print) Linking ISSN: 01434160 NLM ISO Abbreviation: Cell Calcium Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: Amsterdam : Elsevier Original Publication: [Edinburgh, New York] Churchill Livingston |
| مواضيع طبية MeSH: | Calcium/*metabolism , Calcium Channels/*genetics , Calcium Channels/*metabolism , Gene Expression Regulation, Neoplastic/*genetics, 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology ; Animals ; Antisense Elements (Genetics)/genetics ; Base Sequence ; Calcium Channel Agonists/pharmacology ; Calcium Channel Blockers/pharmacology ; Carcinoma/chemically induced ; Carcinoma/genetics ; Carcinoma/pathology ; Cell Division/genetics ; Cell Division/physiology ; DNA Primers/chemistry ; Dihydropyridines/pharmacology ; Dose-Response Relationship, Drug ; Mollusk Venoms/pharmacology ; Pancreas/cytology ; Pancreatic Neoplasms/chemically induced ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Polymerase Chain Reaction ; Rats ; Tumor Cells, Cultured |
| مستخلص: | For the first time, we have demonstrated in AR4-2J cells, an experimental model of azaserine-induced carcinoma in the rat exocrine pancreas, the co-expression of alpha 1 subunit of dihydropyridine-sensitive Ca2+ channel and the alpha 1 sub-unit of omega-conotoxin-sensitive Ca2+ channel RNA messengers which share homologous sequences with, respectively, rbC II and rbB I sub-types described in the rat brain. These two types of voltage-dependent Ca2+ channels which are functionally expressed, emphasize the acquisition during carcinogenesis of neuroendocrine features of AR4-2J cells. Additionally, using antisense phosphorothioate oligodeoxynucleotide, we demonstrated clearly the involvement of dihydropyridine-sensitive Ca2+ channels in the control of AR4-2J cell proliferation. |
| المشرفين على المادة: | 0 (Antisense Elements (Genetics)) 0 (Calcium Channel Agonists) 0 (Calcium Channel Blockers) 0 (Calcium Channels) 0 (DNA Primers) 0 (Dihydropyridines) 0 (Mollusk Venoms) 71145-03-4 (3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 19960601 Date Completed: 19970505 Latest Revision: 20190920 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/s0143-4160(96)90058-5 |
| PMID: | 8842516 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0143-4160 |
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| DOI: | 10.1016/s0143-4160(96)90058-5 |