دورية أكاديمية
Inactivation of photosensitizing merocyanine dyes by plasma, serum and serum components.
| العنوان: | Inactivation of photosensitizing merocyanine dyes by plasma, serum and serum components. |
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| المؤلفون: | Anderson GS; Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA., Günther WH, Searle R, Bilitz JM, Krieg M, Sieber F |
| المصدر: | Photochemistry and photobiology [Photochem Photobiol] 1996 Oct; Vol. 64 (4), pp. 683-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Photobiology Country of Publication: United States NLM ID: 0376425 Publication Model: Print Cited Medium: Print ISSN: 0031-8655 (Print) Linking ISSN: 00318655 NLM ISO Abbreviation: Photochem Photobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004->: Lawrence KS : American Society for Photobiology Original Publication: Augusta, GA: American Society for Photobiology, <1996-> |
| مواضيع طبية MeSH: | Photosensitizing Agents/*blood , Pyrimidinones/*blood, Blood Proteins/metabolism ; Fluorescent Dyes/metabolism ; Fluorescent Dyes/pharmacology ; Humans ; Photosensitizing Agents/pharmacology ; Pyrimidinones/pharmacology |
| مستخلص: | Merocyanine dyes with an oxygen in the electron donor heterocycle were rapidly degraded by plasma, serum and serum components. Replacement of the oxygen by a sulfur or selenium atom rendered the dyes refractory to degradation. The degradation of labile merocyanine dyes was temperature dependent and oxygen independent. The plasma component that was responsible for the degradation of merocyanine dyes was sensitive to heat and detergent, suggesting an enzymatic process. The identification of the structural requirements for sensitivity/resistance to degradation provides the experimenter with a simple means to manipulate the stability of merocyanines in high serum or plasma environments and may expand the clinical utility of merocyanine photosensitizers beyond their traditional role in the extracorporeal purging of bone marrow grafts. |
| معلومات مُعتمدة: | CA49089 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Blood Proteins) 0 (Fluorescent Dyes) 0 (Photosensitizing Agents) 0 (Pyrimidinones) 58823-12-4 (merocyanine dye) |
| تواريخ الأحداث: | Date Created: 19961001 Date Completed: 19970213 Latest Revision: 20190818 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1751-1097.1996.tb03124.x |
| PMID: | 8863474 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0031-8655 |
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| DOI: | 10.1111/j.1751-1097.1996.tb03124.x |