دورية أكاديمية
1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine.
| العنوان: | 1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine. |
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| المؤلفون: | Chiarini A; Department of Pharmaceutical Sciences, University of Bologna, Italy., Rampa A, Budriesi R, Bisi A, Fabbri G, Valenti P |
| المصدر: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 1996 Oct; Vol. 4 (10), pp. 1629-35. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print Cited Medium: Print ISSN: 0968-0896 (Print) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford : New York : Pergamon Press, c1993- |
| مواضيع طبية MeSH: | Calcium Channel Blockers/*chemistry , Dihydropyridines/*chemistry , Lidoflazine/*chemistry , Vasodilator Agents/*chemistry, Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/metabolism ; Calcium Channel Blockers/pharmacology ; Dihydropyridines/pharmacology ; Female ; Guinea Pigs ; Heart/drug effects ; Lidoflazine/pharmacology ; Male ; Myocardial Contraction/drug effects ; Vasodilator Agents/pharmacology |
| مستخلص: | A series of 1,4-dihydropyridines bearing a pharmacophoric fragment of lidoflazine was synthesized. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist activities. All compounds behave as inotropic and chronotropic agents, except for compounds 4b, 5a, and 5b, which exhibit a rather weak calcium antagonism in vascular smooth muscle (like aorta). Compound 5b is about twofold more potent in decreasing both chronotropy and inotropy, while compound 5c is about fivefold more potent in decreasing inotropy than nifedipine. Moreover, compound 5b is the most potent calcium antagonist derivative of the series. |
| المشرفين على المادة: | 0 (Calcium Channel Blockers) 0 (Dihydropyridines) 0 (Vasodilator Agents) 7M8K3P6I89 (1,4-dihydropyridine) J4ZHN3HBTE (Lidoflazine) |
| تواريخ الأحداث: | Date Created: 19961001 Date Completed: 19970303 Latest Revision: 20190830 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1016/0968-0896(96)00155-1 |
| PMID: | 8931932 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0968-0896 |
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| DOI: | 10.1016/0968-0896(96)00155-1 |