التفاصيل البيبلوغرافية
| العنوان: |
Linkage studies in bipolar affective disorder with markers on chromosome 21. |
| المؤلفون: |
Vallada H; Department of Psychological Medicine, Institute of Psychiatry, London, UK., Craddock N, Vasques L, Curtis D, Kirov G, Lauriano V, Gentil V, Passos-Bueno R, Murray RM, Zatz M, McGuffin P, Powell JF, Gill M, Owen M, Collier DA |
| المصدر: |
Journal of affective disorders [J Affect Disord] 1996 Dec 16; Vol. 41 (3), pp. 217-21. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print Cited Medium: Print ISSN: 0165-0327 (Print) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: |
Chromosomes, Human, Pair 21*, Bipolar Disorder/*genetics , Genetic Linkage/*genetics , Genetic Markers/*genetics, Brazil ; Depressive Disorder/genetics ; Europe ; Gene Frequency/genetics ; Humans ; Models, Genetic ; Phenotype ; Psychotic Disorders/genetics |
| مستخلص: |
Straub et al. (1994: Nature Genet. 8. 291-296) have suggested that a susceptibility gene for bipolar affective disorder is located at chromosome 21q22.3, on the basis of linkage analysis in one large family. This result has been supported by Gurling et al. (1995: Nature Genet. 10, 8-9) who also found some evidence for linkage to this region under locus heterogeneity. In order to investigate the validity of these results and to estimate how broadly applicable they are, we performed a linkage study between bipolar affective disorder and two DNA markers (D21S171 and PFKL) from 21q22.3 using 60 bipolar pedigrees from three European centres and Brazil. The most positive result obtained was a maximised admixture lod score of 1.2 for the marker PFKI, under the assumption of locus heterogeneity, dominant transmission and a diagnostic classification which included recurrent unipolar depression. However, since lod scores obtained for both markers were substantially negative overall, we conclude that there is no common major gene for bipolar affective disorder at 21q22.3. It remains possible that a gene of major effect in this region operates in a minority of families. |
| المشرفين على المادة: |
0 (Genetic Markers) |
| تواريخ الأحداث: |
Date Created: 19961216 Date Completed: 19970402 Latest Revision: 20190905 |
| رمز التحديث: |
20221213 |
| DOI: |
10.1016/s0165-0327(96)00055-9 |
| PMID: |
8988454 |
| قاعدة البيانات: |
MEDLINE |
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