دورية أكاديمية
Patient-specific dosimetry using quantitative SPECT imaging and three-dimensional discrete Fourier transform convolution.
| العنوان: | Patient-specific dosimetry using quantitative SPECT imaging and three-dimensional discrete Fourier transform convolution. |
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| المؤلفون: | Akabani G; Department of Radiation Oncology, University of Nebraska Medical Center, Omaha 68198-1045, USA., Hawkins WG, Eckblade MB, Leichner PK |
| المصدر: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 1997 Feb; Vol. 38 (2), pp. 308-14. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print Cited Medium: Print ISSN: 0161-5505 (Print) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Reston, VA : Society of Nuclear Medicine Original Publication: [Chicago, Ill.] : S.N. Turiel & Assoc. |
| مواضيع طبية MeSH: | Models, Theoretical* , Radioimmunotherapy* , Radiotherapy Planning, Computer-Assisted* , Tomography, Emission-Computed, Single-Photon*, Algorithms ; Fourier Analysis ; Humans ; Iodine Radioisotopes ; Monte Carlo Method ; Phantoms, Imaging ; Radioimmunodetection |
| مستخلص: | Unlabelled: The objective of this study was to develop a three-dimensional discrete Fourier transform (3D-DFT) convolution method to perform the dosimetry for 131I-labeled antibodies in soft tissues. Methods: Mathematical and physical phantoms were used to compare 3D-DFT with Monte Carlo transport (MCT) calculations based on the EGS4 code. The mathematical and physical phantoms consisted of a sphere and a cylinder, respectively, containing uniform and non-uniform activity distributions. Quantitative SPECT reconstruction was carried out using the circular harmonic transform (CHT) algorithm. Results: The radial dose profile obtained from MCT calculations and the 3D-DFT convolution method for the mathematical phantom were in close agreement. The root mean square error (RMSE) for the two methods was < 0.1%, with a maximum difference < 21%. Results obtained for the physical phantom gave a RMSE < 0.1% and a maximum difference of < 13%; isodose contours were in good agreement. SPECT data for two patients who had undergone 131I radioimmunotherapy (RIT) were used to compare absorbed-dose rates and isodose rate contours with the two methods of calculation. This yielded a RMSE < 0.02% and a maximum difference of < 13%. Conclusion: Our results showed that the 3D-DFT convolution method compared well with MCT calculations. The 3D-DFT approach is computationally much more efficient and, hence, the method of choice. This method is patient-specific and applicable to the dosimetry of soft-tissue tumors and normal organs. It can be implemented on personal computers. |
| معلومات مُعتمدة: | U01 CA58272-03 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Iodine Radioisotopes) |
| تواريخ الأحداث: | Date Created: 19970201 Date Completed: 19970305 Latest Revision: 20071114 |
| رمز التحديث: | 20221213 |
| PMID: | 9025760 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0161-5505 |
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