دورية أكاديمية
[Hypertension caused by licorice consumption].
| العنوان: | [Hypertension caused by licorice consumption]. |
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| عنوان ترانسليتريتد: | Hypertensie door dropgebruik. |
| المؤلفون: | Seelen MA; Academisch Ziekenhuis, afd. Interne Geneeskunde, Leiden., de Meijer PH, Braun J, Swinkels LM, Waanders H, Meinders AE |
| المصدر: | Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 1996 Dec 28; Vol. 140 (52), pp. 2632-5. |
| نوع المنشور: | Case Reports; English Abstract; Journal Article |
| اللغة: | Dutch; Flemish |
| بيانات الدورية: | Publisher: Vereniging NTvG Country of Publication: Netherlands NLM ID: 0400770 Publication Model: Print Cited Medium: Print ISSN: 0028-2162 (Print) Linking ISSN: 00282162 NLM ISO Abbreviation: Ned Tijdschr Geneeskd Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017?-: Amsterdam : Vereniging NTvG Original Publication: Houten : Bohn Stafleu van Loghum |
| مواضيع طبية MeSH: | Glycyrrhiza* , Plants, Medicinal*, Glycyrrhetinic Acid/*adverse effects , Hypertension/*chemically induced, 11-beta-Hydroxysteroid Dehydrogenases ; Adult ; Alkalosis/chemically induced ; Alkalosis/complications ; Female ; Glycyrrhetinic Acid/pharmacology ; Humans ; Hydroxysteroid Dehydrogenases/antagonists & inhibitors ; Hypertension/complications ; Hypokalemia/chemically induced ; Hypokalemia/complications ; Kidney/metabolism |
| مستخلص: | In a 38-year-old woman who was hospitalized because of hypertension and hypokalaemic alkalosis, the intake of liquorice (200 g per day) was proven to be the cause. A liquorice provocation test produced all the expected clinical and biochemical abnormalities. Some kinds of liquorice contain glycyrrhetic acid which inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase (e.g. in the kidney) leading to decreased transformation of cortisol into cortisone. The mineralocorticoid action of cortisol causes a drop in serum potassium and an increase in serum sodium concentration, together with a metabolic alkalosis, which in the patient described led to retention of water resulting in weight increase and hypertension. |
| التعليقات: | Erratum in: Ned Tijdschr Geneeskd 1997 Jan 18;141(3):176. Meijer PH [corrected to de Meijer PH]. |
| المشرفين على المادة: | EC 1.1.- (Hydroxysteroid Dehydrogenases) EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases) P540XA09DR (Glycyrrhetinic Acid) |
| تواريخ الأحداث: | Date Created: 19961228 Date Completed: 19970220 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 9026743 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0028-2162 |
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