دورية أكاديمية
Radioprotective efficacy of HT + AET in encapsulated form.
| العنوان: | Radioprotective efficacy of HT + AET in encapsulated form. |
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| المؤلفون: | Upadhyay SN; Radiation Biology Department, Institute of Nuclear Medicine & Allied Sciences, Delhi, India., Dey TB, Ghose A |
| المصدر: | Indian journal of experimental biology [Indian J Exp Biol] 1996 May; Vol. 34 (5), pp. 403-7. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Institute of Science Communication and Information Resources, CSIR Country of Publication: India NLM ID: 0233411 Publication Model: Print Cited Medium: Print ISSN: 0019-5189 (Print) Linking ISSN: 00195189 NLM ISO Abbreviation: Indian J Exp Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New Delhi : National Institute of Science Communication and Information Resources, CSIR Original Publication: New Delhi, Council of Scientific & Industrial Research. |
| مواضيع طبية MeSH: | Radiation-Protective Agents/*administration & dosage , Serotonin/*administration & dosage , beta-Aminoethyl Isothiourea/*administration & dosage, Animals ; Drug Compounding/methods ; Electricity ; Erythrocyte Membrane ; In Vitro Techniques ; Male ; Mice ; Rabbits ; Radiation-Protective Agents/pharmacokinetics ; Serotonin/blood ; beta-Aminoethyl Isothiourea/pharmacokinetics |
| مستخلص: | Entrapment of 5-hydroxyl-L-tryptophan (HT) in erythrocyte ghost prepared by hypotonic method and high voltage electric discharge method are nearly same. Release of HT with beta-aminoethylisothiuronium bromide hydrobromide (HT + AET) in in vitro system is rapid but only a portion of the entrapped amount is released. Release of HT + AET in serum marginally increases at 2 hr. Compared to release in in vitro medium the release in serum is less. Survival studies with Swiss albino mice indicates that compared to HT alone, the combination of HT + AET shows about 9 times percentage survival. The same combination in the encapsulated form show comparable percentage survival though the amount needed is 1/200th times compared to free form. |
| المشرفين على المادة: | 0 (Radiation-Protective Agents) 151-16-6 (beta-Aminoethyl Isothiourea) 333DO1RDJY (Serotonin) |
| تواريخ الأحداث: | Date Created: 19960501 Date Completed: 19970417 Latest Revision: 20141120 |
| رمز التحديث: | 20231215 |
| PMID: | 9063072 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0019-5189 |
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