دورية أكاديمية
Stress proteins and atherosclerosis.
| العنوان: | Stress proteins and atherosclerosis. |
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| المؤلفون: | Roma P; Institute of Pharmacological Sciences, University of Milano, Italy., Catapano AL |
| المصدر: | Atherosclerosis [Atherosclerosis] 1996 Dec 20; Vol. 127 (2), pp. 147-54. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print Cited Medium: Print ISSN: 0021-9150 (Print) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Arteriosclerosis*/etiology , Arteriosclerosis*/immunology , Arteriosclerosis*/metabolism, Heat-Shock Proteins/*physiology, Animals ; Chaperonin 60/physiology ; HSP70 Heat-Shock Proteins/physiology ; Humans ; Risk Factors |
| مستخلص: | Several cytotoxic stimuli of a different nature are involved in the complex etiology of atherosclerosis. Cells of the vasculature may potentially cope with the presence of these stressors through the increased synthesis of stress proteins (or heat shock proteins, hsps), an ubiquitous and conserved defense response. Evidence exists that the expression of two stress proteins of intermediate molecular weight, hsp60 and hsp70, is higher at sites of atherosclerotic lesions than it is in normal tissue. The role of hsps in atherosclerosis is controversial. While hsp70 is likely to be involved in cytoprotection, hsp60 is probably acting as an autoantigen, and may trigger both cell-mediated and antibody-mediated immune responses. |
| Number of References: | 97 |
| المشرفين على المادة: | 0 (Chaperonin 60) 0 (HSP70 Heat-Shock Proteins) 0 (Heat-Shock Proteins) |
| تواريخ الأحداث: | Date Created: 19961220 Date Completed: 19970421 Latest Revision: 20190718 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/s0021-9150(96)05952-7 |
| PMID: | 9125304 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0021-9150 |
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| DOI: | 10.1016/s0021-9150(96)05952-7 |