دورية أكاديمية
Endogenous retroviral sequences in the pathogenesis of systemic autoimmune disease.
| العنوان: | Endogenous retroviral sequences in the pathogenesis of systemic autoimmune disease. |
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| المؤلفون: | Walchner M; Department of Dermatology, Ludwig-Maximilians-Universität, München, Germany., Leib-Mösch C, Messer G, Germaier H, Plewig G, Kind P |
| المصدر: | Archives of dermatology [Arch Dermatol] 1997 Jun; Vol. 133 (6), pp. 767-71. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Assn Country of Publication: United States NLM ID: 0372433 Publication Model: Print Cited Medium: Print ISSN: 0003-987X (Print) Linking ISSN: 0003987X NLM ISO Abbreviation: Arch Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, American Medical Assn. |
| مواضيع طبية MeSH: | Autoimmune Diseases/*virology , Retroviridae/*genetics, Genes, Viral/genetics ; Humans |
| مستخلص: | Objectives: To update information on endogenous retroviral sequences and discuss their role in systemic autoimmune disease. Data Sources: Articles retrieved after MEDLINE search and personal communications and cooperation with the Institute of Virology. Data Synthesis: There are 2 modes of pathogenetic mechanisms through which endogenous retroviral sequences could cause systemic autoimmune disease: expression of endogenous retroviral gene products sharing antigenic determinants with cellular proteins; and activation or destruction of cellular genes as a consequence of insertional mutagenesis. Both mechanisms have been demonstrated in vitro and in vivo in animal models. Conclusion: Investigations on endogenous retroviral sequences in humans may offer new insights into the pathogenesis of autoimmune disease. |
| Number of References: | 69 |
| تواريخ الأحداث: | Date Created: 19970601 Date Completed: 19970718 Latest Revision: 20080317 |
| رمز التحديث: | 20240628 |
| PMID: | 9197833 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0003-987X |
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