دورية أكاديمية
Nucleus reuniens thalami modulates activity in hippocampal field CA1 through excitatory and inhibitory mechanisms.
| العنوان: | Nucleus reuniens thalami modulates activity in hippocampal field CA1 through excitatory and inhibitory mechanisms. |
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| المؤلفون: | Dolleman-Van der Weel MJ; Graduate School for Neurosciences Amsterdam, Research Institute for Neurosciences, Faculty of Medicine, Department of Anatomy and Embryology, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands., Lopes da Silva FH, Witter MP |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 1997 Jul 15; Vol. 17 (14), pp. 5640-50. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Print ISSN: 0270-6474 (Print) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Hippocampus/*physiology , Synaptic Transmission/*physiology , Thalamic Nuclei/*physiology, Animals ; Hippocampus/anatomy & histology ; Male ; Rats ; Rats, Wistar ; Thalamic Nuclei/anatomy & histology |
| مستخلص: | The nucleus reuniens thalami (RE) originates dense projections to CA1, forming asymmetrical synapses on spines (50%) and dendrites (50%). The hypothesis that RE input modulates transmission in CA1 through excitation of both pyramidal cells and interneurons was tested using electrophysiological methods in the anesthetized rat. The RE-CA1 afferents were selectively stimulated at their origin; evoked field potentials and unit activity were recorded in CA1. RE-evoked depth profiles showed a prominent negative deflection in the stratum lacunosum-moleculare and a positive one in the stratum radiatum. The lacunosum-moleculare sink-radiatum source configuration is compatible with RE-elicited depolarization of apical dendrites of pyramidal cells. Despite a consistent and robust paired pulse facilitation of RE-evoked field potentials, population spikes in the stratum pyramidale were not detected at any tested condition. This indicates the inability of RE-CA1 input to discharge pyramidal cells. However, stimulation of RE-elicited spiking of extracellularly recorded units in strata oriens/alveus and distal radiatum, indicative of the activation of local interneurons. Thus, RE seems to modulate transmission in CA1 through a (subthreshold) depolarization of pyramidal cells and a suprathreshold excitation of putative inhibitory oriens/alveus and radiatum interneurons. RE-evoked monosynaptic or disynaptic field potentials were associated with stimulation of rostral or caudal RE, respectively. Anatomically, a projection from caudal to rostral RE was demonstrated that can account for the disynaptic RE-CA1 input. Because caudal RE receives input from the hippocampus via the subiculum, we propose the existence of a closed RE-hippocampal circuit that allows RE to modulate the activity in CA1, depending on hippocampal output. |
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| تواريخ الأحداث: | Date Created: 19970715 Date Completed: 19970721 Latest Revision: 20240720 |
| رمز التحديث: | 20240720 |
| مُعرف محوري في PubMed: | PMC6793818 |
| PMID: | 9204945 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0270-6474 |
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