دورية أكاديمية
In vitro antimicrobial activity of the thiazolyl peptide antibiotic MDL 62,879 (GE2270 A).
| العنوان: | In vitro antimicrobial activity of the thiazolyl peptide antibiotic MDL 62,879 (GE2270 A). |
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| المؤلفون: | Kenny MT; Hoechst Marion Roussel, Kansas City, Mo. 64134, USA., Brackman MA, Dulworth JK |
| المصدر: | Chemotherapy [Chemotherapy] 1997 Jul-Aug; Vol. 43 (4), pp. 254-63. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0144731 Publication Model: Print Cited Medium: Print ISSN: 0009-3157 (Print) Linking ISSN: 00093157 NLM ISO Abbreviation: Chemotherapy Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, New York, Karger. |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Gram-Positive Bacteria/*drug effects, Microbial Sensitivity Tests ; Peptides, Cyclic/pharmacology ; Teicoplanin/pharmacology ; Thiazoles/pharmacology ; Vancomycin/pharmacology |
| مستخلص: | Compound MDL 62,879 (GE2270 A) is a thiazolyl peptide antibiotic that appears to inhibit aminoacyl-tRNA binding to elongation factor Tu. In the present study, it was shown that MDL 62,879 broth microdilution MIC values were generally 2-4 doubling dilutions lower in the presence of 0.02% bovine serum albumin. Using US clinical isolates and BSA-supplemented media, MDL 62,879 was more active than teicoplanin and vancomycin against the staphylococci and glycopeptide-resistant and glycopeptide-susceptible enterococci and equally active against the streptococci. Broth microdilutions MIC values were not appreciably affected by inoculum concentrations of 5 x 10(4) to 5 x 10(8) cfu/ml or in the presence of 3.5% human serum albumin. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Peptides, Cyclic) 0 (Thiazoles) 61036-62-2 (Teicoplanin) 6Q205EH1VU (Vancomycin) JB4J58L2K1 (GE 2270 A) |
| تواريخ الأحداث: | Date Created: 19970701 Date Completed: 19970821 Latest Revision: 20180216 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1159/000239576 |
| PMID: | 9209782 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0009-3157 |
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| DOI: | 10.1159/000239576 |