دورية أكاديمية
Glial growth factor rescues Schwann cells of mechanoreceptors from denervation-induced apoptosis.
| العنوان: | Glial growth factor rescues Schwann cells of mechanoreceptors from denervation-induced apoptosis. |
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| المؤلفون: | Kopp DM; Department of Zoology, University of Texas at Austin, Austin, Texas 78712, USA., Trachtenberg JT, Thompson WJ |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 1997 Sep 01; Vol. 17 (17), pp. 6697-706. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Print ISSN: 0270-6474 (Print) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Denervation*, Apoptosis/*drug effects , Growth Inhibitors/*pharmacology , Mechanoreceptors/*drug effects , Nerve Tissue Proteins/*pharmacology , Schwann Cells/*drug effects, Animals ; Axons/metabolism ; Glia Maturation Factor ; Glycoproteins/metabolism ; Immunohistochemistry ; Mechanoreceptors/physiology ; Neuregulins ; Rats ; Rats, Wistar ; Receptor, ErbB-2 ; Receptors, Nerve Growth Factor/metabolism ; Schwann Cells/metabolism ; Schwann Cells/physiology |
| مستخلص: | Golgi tendon organs and Pacinian corpuscles are peripheral mechanoreceptors that disappear after denervation during a critical period in early postnatal development. Even if regeneration is allowed to occur, Golgi tendon organs do not reform, and the reformation of Pacinian corpuscles is greatly impaired. The sensory nerve terminals of both types of mechanoreceptors are closely associated with Schwann cells. Here we investigate the changes in the Schwann cells found in Golgi tendon organs and Pacinian corpuscles after nerve resection in the early neonatal period. We report that denervation induces the apoptotic death of these Schwann cells and that this apoptosis can be prevented by administration of a soluble form of neuregulin, glial growth factor 2. Schwann cells associated with these mechanoreceptors are immunoreactive for the neuregulin receptors erbB2, erbB3, and erbB4, and the sensory nerve terminals are immunoreactive for neuregulin. Our results suggest that Schwann cells in developing sensory end organs are trophically dependent on sensory axon terminals and that an axon-derived neuregulin mediates this trophic interaction. The denervation-induced death of mechanoreceptor Schwann cells is correlated with deficiencies in the re-establishment of these sensory end organs by regenerating axons. |
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| معلومات مُعتمدة: | NS 20480 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Glia Maturation Factor) 0 (Glycoproteins) 0 (Growth Inhibitors) 0 (Nerve Tissue Proteins) 0 (Neuregulins) 0 (Receptors, Nerve Growth Factor) EC 2.7.10.1 (Receptor, ErbB-2) |
| تواريخ الأحداث: | Date Created: 19970901 Date Completed: 19970923 Latest Revision: 20191025 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6573136 |
| PMID: | 9254682 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0270-6474 |
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