دورية أكاديمية
Protective effect of Livex, a herbal formulation against erythromycin estolate induced hepatotoxicity in rats.
| العنوان: | Protective effect of Livex, a herbal formulation against erythromycin estolate induced hepatotoxicity in rats. |
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| المؤلفون: | Venkateswaran S; Department of Biochemistry, Annamalai University, Tamil Nadu, India., Pari L, Viswanathan P, Menon VP |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 1997 Aug; Vol. 57 (3), pp. 161-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print Cited Medium: Print ISSN: 0378-8741 (Print) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*toxicity , Erythromycin Estolate/*toxicity , Liver/*drug effects , Plant Extracts/*pharmacology, Administration, Oral ; Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Animals ; Anti-Bacterial Agents/administration & dosage ; Aspartate Aminotransferases/blood ; Bilirubin/blood ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/prevention & control ; Erythromycin Estolate/administration & dosage ; Lipids/blood ; Liver/cytology ; Liver/pathology ; Male ; Plants, Medicinal ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar |
| مستخلص: | Livex, a compound herbal formulation, was investigated for its possible hepatoprotective effect in Wistar rats against erythromycin estolate induced toxicity. Oral administration of Livex significantly prevented the occurrence of erythromycin estolate induced hepatic damage. The increased level of serum enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase), bilirubin, serum and tissue cholesterol, triglycerides, phospholipids and free fatty acids observed in rats treated with erythromycin estolate were very much reduced in rats treated with Livex and erythromycin estolate. These biochemical observations were supplemented by histopathological examination of liver sections. Results of this study revealed that Livex could afford a significant protection against erythromycin estolate induced hepatocellular damage. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Lipids) 0 (Plant Extracts) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) EC 3.1.3.1 (Alkaline Phosphatase) RFM9X3LJ49 (Bilirubin) XRJ2P631HP (Erythromycin Estolate) |
| تواريخ الأحداث: | Date Created: 19970801 Date Completed: 19980108 Latest Revision: 20190831 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/s0378-8741(97)00062-7 |
| PMID: | 9292408 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0378-8741 |
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| DOI: | 10.1016/s0378-8741(97)00062-7 |