دورية أكاديمية
Hormone replacement therapy and the risk of breast lesions that predispose to cancer.
| العنوان: | Hormone replacement therapy and the risk of breast lesions that predispose to cancer. |
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| المؤلفون: | Cahn MD; Department of Surgery, University of California, Irvine Medical Center 92668, USA., Tran T, Theur CP, Butler JA |
| المصدر: | The American surgeon [Am Surg] 1997 Oct; Vol. 63 (10), pp. 858-60. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications in association with Southeastern Surgical Congress Country of Publication: United States NLM ID: 0370522 Publication Model: Print Cited Medium: Print ISSN: 0003-1348 (Print) Linking ISSN: 00031348 NLM ISO Abbreviation: Am Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Thousand Oaks, CA] : SAGE Publications in association with Southeastern Surgical Congress Original Publication: Atlanta Ga : Southeastern Surgical Congress |
| مواضيع طبية MeSH: | Breast Diseases/*complications , Breast Neoplasms/*etiology , Estrogen Replacement Therapy/*adverse effects , Precancerous Conditions/*etiology, Adult ; Aged ; Aged, 80 and over ; Biopsy ; Breast Neoplasms/chemically induced ; Chi-Square Distribution ; Cocarcinogenesis ; Disease Susceptibility ; Epithelium/pathology ; Female ; Fibroadenoma/complications ; Fibrocystic Breast Disease/complications ; Humans ; Hyperplasia ; Mammography ; Middle Aged ; Odds Ratio ; Papilloma, Intraductal/complications ; Physical Examination ; Population Surveillance ; Postmenopause ; Precancerous Conditions/chemically induced ; Retrospective Studies |
| مستخلص: | To determine whether postmenopausal individuals being treated with hormone replacement therapy (HRT) have an increased risk for lesions that predispose to breast cancer, 156 women with benign breast lesions were retrospectively studied. Their ages ranged from 43 to 88. Each patient underwent a breast biopsy from 1991 to 1995. It was determined from chart review whether each of these patients had been treated with HRT. Fifty-seven of these patients had a biopsy finding that predisposed the patient to future breast cancer. The predisposing lesions included sclerosing adenosis, intraductal papilloma, and epithelial hyperplasia with atypia. Of these 57 patients, 36 (63%) were being treated with HRT. Only 30 of the 99 patients (30%) with nonproliferative lesions were treated with HRT (odds ratio, 3.9; P < 0.0005). On the basis of the results of this study, we believe that the use of HRT may promote lesions that predispose to cancer. This suggests that patients treated with HRT require vigilant surveillance by way of examination and mammography. |
| تواريخ الأحداث: | Date Created: 19971010 Date Completed: 19971030 Latest Revision: 20061115 |
| رمز التحديث: | 20240627 |
| PMID: | 9322657 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0003-1348 |
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