دورية أكاديمية
Abnormal endothelium-dependent responses in early radiation nephropathy.
| العنوان: | Abnormal endothelium-dependent responses in early radiation nephropathy. |
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| المؤلفون: | Juncos LI; Instituto Privado de Especialidades Médicas, Córdoba, Argentina., Cornejo JC, Gomes J, Baigorria S, Juncos LA |
| المصدر: | Hypertension (Dallas, Tex. : 1979) [Hypertension] 1997 Sep; Vol. 30 (3 Pt 2), pp. 672-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print Cited Medium: Print ISSN: 0194-911X (Print) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]- |
| مواضيع طبية MeSH: | Endothelium, Vascular/*radiation effects , Kidney/*radiation effects, Acetylcholine/pharmacology ; Angiotensin II/pharmacology ; Animals ; Blood Pressure/radiation effects ; Endothelium, Vascular/physiology ; Indomethacin/pharmacology ; NG-Nitroarginine Methyl Ester/pharmacology ; Rats ; Renal Circulation/radiation effects ; Vasodilation/drug effects |
| مستخلص: | While arterial hypertension and renal dysfunction are well recognized complications of renal irradiation, the mechanisms that trigger the development of these complications are unknown. Recently, it was reported that the endothelium is a major target in radiation injury. Because dysfunction of the endothelial cells may lead or contribute to the development of hypertension and renal dysfunction in radiation nephropathy, we tested the hypothesis that endothelium-dependent vasodilation is impaired in radiated kidneys prior to the onset of hypertension. To test this hypothesis, we used Long-Evans rats that had undergone left nephrectomy (3 weeks earlier) and irradiation (3000 r's) to the right kidney 8 days earlier (mean blood pressures in the irradiated rats were not different than in the controls). We then measured the changes in renal blood flow (RBF) induced by endothelium-dependent (acetylcholine and bradykinin) and -independent (nitroprusside, norepinephrine, and angiotensin II) vasoactive agents. We found that the increases in RBF induced by the endothelium-dependent but not independent vasodilators were markedly impaired in the irradiated kidneys. Blocking nitric oxide synthesis with nitro L-arginine methyl ester in sham rats mimicked the blunted responsiveness of the irradiated rats, whereas indomethacin (an inhibitor of prostaglandin synthesis) had no effect on either sham or irradiated rats. Finally, the RBF responses to the endothelium-independent vasoconstrictors, norepinephrine and angiotensin II, were not altered in the irradiated kidneys. These results suggest that renal irradiation causes endothelial dysfunction (prior to the onset of hypertension) but spares the vascular smooth muscle cells. |
| المشرفين على المادة: | 11128-99-7 (Angiotensin II) N9YNS0M02X (Acetylcholine) V55S2QJN2X (NG-Nitroarginine Methyl Ester) XXE1CET956 (Indomethacin) |
| تواريخ الأحداث: | Date Created: 19971010 Date Completed: 19971016 Latest Revision: 20190722 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1161/01.hyp.30.3.672 |
| PMID: | 9323003 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0194-911X |
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| DOI: | 10.1161/01.hyp.30.3.672 |