دورية أكاديمية
Circulating immune complexes in lupus erythematosus, scleroderma and dermatomyositis.
| العنوان: | Circulating immune complexes in lupus erythematosus, scleroderma and dermatomyositis. |
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| المؤلفون: | Sølling J, Sølling K, Jacobsen KU |
| المصدر: | Acta dermato-venereologica [Acta Derm Venereol] 1979; Vol. 59 (5), pp. 421-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MJS Publishing Country of Publication: Sweden NLM ID: 0370310 Publication Model: Print Cited Medium: Print ISSN: 0001-5555 (Print) Linking ISSN: 00015555 NLM ISO Abbreviation: Acta Derm Venereol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : Uppsala, Sweden : MJS Publishing Original Publication: Stockholm : Acta dermato-venereologica |
| مواضيع طبية MeSH: | Antigen-Antibody Complex*, Dermatomyositis/*immunology , Lupus Erythematosus, Systemic/*immunology , Scleroderma, Systemic/*immunology, Chemical Precipitation ; Complement C1/metabolism ; Complement C3/metabolism ; Complement C4/metabolism ; Deoxyribonucleases/therapeutic use ; Female ; Humans ; Immunologic Techniques ; Lupus Erythematosus, Systemic/drug therapy ; Male ; Polyethylene Glycols ; Radioimmunoassay ; Receptors, Complement |
| مستخلص: | Circulating immune complexes (CIC) were measured by three different methods in serum from 17 patients with systemic lupus erythematosus (SLE), 3 patients with "hydralazine-induced" SLE-like syndromes, 14 patients with discoid lupus (DLE), 8 patients with systemic sclerosis and 5 patients with dermatomyositis. Immune complexes were detected in 13 of the 17 patients with SLE. All patients with lupus nephritis and typical exanthema had circulating immune complexes. The concentration of immune complexes was inversely correlated to serum complements C4 and C3. All 3 patients with "hydralazine-induced" SLE-like syndromes had circulating immune complexes that disappeared after withdrawal of the drug. Immune complexes were detected in 3 of the 14 patients with DLE; all 3 patients with CIC had wide-spread DLE. In systemic sclerosis, CIC were detected in only 1 of the 8 patients. Four of the 5 patients with dermatomyositis demonstrated CIC in serum. No complement consumption was detected in dermatomyositis and the immune complexes may have been secondary to tissue destruction. |
| المشرفين على المادة: | 0 (Antigen-Antibody Complex) 0 (Complement C1) 0 (Complement C3) 0 (Complement C4) 0 (Receptors, Complement) 3WJQ0SDW1A (Polyethylene Glycols) EC 3.1.- (Deoxyribonucleases) |
| تواريخ الأحداث: | Date Created: 19790101 Date Completed: 19800317 Latest Revision: 20181130 |
| رمز التحديث: | 20231215 |
| PMID: | 93365 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0001-5555 |
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