دورية أكاديمية
Change of cardiac beta-adrenoceptors in lead-exposed rats.
| العنوان: | Change of cardiac beta-adrenoceptors in lead-exposed rats. |
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| المؤلفون: | Chang HR; Department of Cosmetic Science, Chia-Nan College of Pharmacy and Science, Tainan County, Taiwan., Chen SS, Tsao DA, Cheng JT, Ho CK, Yu HS |
| المصدر: | Toxicology [Toxicology] 1997 Nov 21; Vol. 123 (1-2), pp. 27-32. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print Cited Medium: Print ISSN: 0300-483X (Print) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam. Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Lead/*toxicity , Organometallic Compounds/*toxicity , Receptors, Adrenergic, beta/*drug effects, Animals ; Body Weight/drug effects ; Iodocyanopindolol ; Lead/analysis ; Lead/blood ; Myocardium/chemistry ; Myocardium/metabolism ; Organ Size/drug effects ; Pindolol/analogs & derivatives ; Pindolol/metabolism ; Protein Binding/drug effects ; Rats ; Rats, Wistar ; Receptors, Adrenergic, beta/metabolism |
| مستخلص: | The effect of lead on cardiac beta-adrenoceptors was studied. Wistar rats used in these trials were divided into seven groups of ten animals each (A-G). Of these, groups B was given drinking water containing 0.01% lead acetate, group C 0.05%, group D 0.1%, group E 0.5%, group F 1% and group G 2% for a period of 60 days. Group A was given pure water. A radioligand-binding assay fulfilling strict criteria of receptor affinity and density was used to quantify cardiac beta-adrenoceptors. Application of a trend test indicated that both blood and heart lead levels increased significantly from group A to group G (A < G), but that beta-adrenoceptor density decreased (G < A), whereas Kd did not vary among the seven groups. Linear regression analysis showed that decrease of cardiac beta-adrenergic receptor density was closely related to elevation of blood and heart lead levels. The results show that lead exposure results in a reduction of cardiac beta-adrenoceptor density. |
| المشرفين على المادة: | 0 (Organometallic Compounds) 0 (Receptors, Adrenergic, beta) 2P299V784P (Lead) 83498-72-0 (Iodocyanopindolol) BJ4HF6IU1D (Pindolol) RX077P88RY (lead acetate) |
| تواريخ الأحداث: | Date Created: 19971105 Date Completed: 19971106 Latest Revision: 20190819 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0300-483x(97)00100-5 |
| PMID: | 9347921 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0300-483X |
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| DOI: | 10.1016/s0300-483x(97)00100-5 |